| Chen CL |
------>authors3_c=? ------>paper_class1=1 ------>Impact_Factor=11.673 ------>paper_class3=2 ------>paper_class2=1 ------>vol=135 ------>confirm_bywho=hychiou ------>insert_bywho=liyu ------>Jurnal_Rank=2.0 ------>authors4_c=? ------>comm_author= ------>patent_EDate=None ------>authors5_c=? ------>publish_day=20 ------>paper_class2Letter=None ------>page2=121 ------>medlineContent= ------>unit=J0200 ------>insert_date=20081127 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=? ------>score=500 ------>journal_name=Gastroenterology ------>paper_name=Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. ------>confirm_date=20081203 ------>tch_id=097008 ------>pmid=18505690 ------>page1=111 ------>fullAbstract=BACKGROUND & AIMS: This study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (HCC), stratified by hepatitis B virus (HBV) and hepatitis C virus (HCV) serostatus, and explored the possible joint influence of obesity/diabetes and HBV/HCV infections on the risk of HCC. METHODS: A total of 23,820 residents in Taiwan were recruited and followed up for 14 years. All analyses were stratified by hepatitis B surface antigen (HBsAg) and antibody to HCV (anti-HCV) at enrollment, and 218 subjects positive for both seromarkers were excluded. Incident HCC cases were identified via linkage to the national cancer registry. Multivariate-adjusted relative risk (RR(a)) and 95% confidence interval (95% CI) were estimated using Cox proportional hazards models. RESULTS: Extreme obesity (body mass index >or=30 kg/m(2)) was independently associated with a 4-fold risk of HCC (RR(a), 4.13; 95% CI, 1.38-12.4) among anti-HCV-seropositive subjects and a 2-fold risk (RR(a), 2.36; 95% CI, 0.91-6.17) in persons without HBV and HCV infections, after controlling for other metabolic components, but not in HBsAg-seropositive subjects (RR(a), 1.36; 95% CI, 0.64-2.89). Diabetes was associated with HCC in all 3 groups, with the highest risk in those with HCV infection (RR(a), 3.52; 95% CI, 1.29-9.24) and lowest in HBV carriers (RR(a), 2.27; 95% CI, 1.10-4.66). We found more than 100-fold increased risk in HBV or HCV carriers with both obesity and diabetes, indicating synergistic effects of metabolic factors and hepatitis. CONCLUSIONS: The finding that both obesity and diabetes are predictors of HCC risk, possibly differently depending on HBV and HCV infection status, may shed some light in preventing HCC. ------>tmu_sno=None ------>sno=19915 ------>authors2=Yang HI ------>authors3=Yang WS ------>authors4=Liu CJ ------>authors5=Chen PJ ------>authors6=You SL, Wang LY ------>authors6_c=?, ??? ------>authors=Chen CL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=? ------>publish_area=0 ------>updateTitle=Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=8 |