Wang LY |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.377 ------>paper_class3=2 ------>paper_class2=1 ------>vol=24 ------>confirm_bywho=hychiou ------>insert_bywho=liyu ------>Jurnal_Rank=1.5 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=4432 ------>medlineContent= ------>unit=J0200 ------>insert_date=20081127 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Vaccine ------>paper_name=Geographic and ethnic variations of long-term efficacy and immunogenicity of hepatitis B vaccination in Hualien, a HBV hyperendemic area ------>confirm_date=20081203 ------>tch_id=097008 ------>pmid=16574284 ------>page1=4427 ------>fullAbstract=It is uncertain whether immunologic memory persists for 15 years or more after immunization and whether the efficacy of universal hepatitis B vaccination program (UHBVP) in socio-economically disadvantaged area with hyperendemicity of hepatitis B virus (HBV) infection is similar. We assayed hepatitis B surface antigen (HBsAg) and antibody to HBsAg (anti-HBs) on 2839 students aged 15 years or more born before (N = 248) and after (N = 2591) UHBVP. We found that students born after UHBVP had significantly lower positive rate of anti-HBs than those born before UHBVP (44.6% versus 75.0%, p<0.0001). Seropositive rate of HBsAg for students born after UHBVP was also declined significantly (1.9% versus 9.3%, p<0.0001). Preventive fraction of UHBVP on HBsAg-seropositivity was 78% (95% confidence interval, 0.64-0.87), which was at least 10% lower than previous studies. Preventive fraction in Han Chinese (74%) and Atayal (78%) students were lower than Amis students (94%). In 2264 Han Chinese students, preventive fraction was 16% lower in those resided in rural than urban areas. These observations indicated that UHBVP was less effective in socio-economically disadvantaged area where HBV infection was hyperendemic and the long-term efficacy and immunogenicity of vaccination were modified by host factors and factors associated with urbanization. ------>tmu_sno=None ------>sno=19926 ------>authors2=Hu CT ------>authors3=Ho TY ------>authors4=Lin HH ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Wang LY ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Geographic and ethnic variations of long-term efficacy and immunogenicity of hepatitis B vaccination in Hualien, a HBV hyperendemic area. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=3 |