| Wang LY |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.468 ------>paper_class3=2 ------>paper_class2=1 ------>vol=32 ------>confirm_bywho=hychiou ------>insert_bywho=liyu ------>Jurnal_Rank=28.0 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=150 ------>medlineContent= ------>unit=J0200 ------>insert_date=20081127 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Journal of Clinical Virology ------>paper_name=Human leukocyte antigen phenotypes and hepatitis C viral load ------>confirm_date=20081203 ------>tch_id=097008 ------>pmid=15653417 ------>page1=144 ------>fullAbstract=BACKGROUND: After hepatitis C virus (HCV) infection, 55% to 85% of patients become chronic carriers. HCV-RNA could be detected in the sera of these patients though the viral load varies. Various factors may be involved in determining the viral load. OBJECTIVES: In this study, we want to investigate the relationship between human leukocyte antigen phenotypes and hepatitis C viral load. STUDY DESIGN: One hundred and sixty HCV-RNA positive subjects were investigated in this study. RESULTS: We have analyzed 160 HCV-RNA positive subjects and found that lower HCV viral load is significantly associated with HBsAg-positivity (P = 0.017) but not age, gender, or mixed infection (infection with different HCV genotypes). One hundred and fifty-four HBsAg-negative subjects were further analyzed to explore the relationship between human leukocyte antigen (HLA) phenotypes and HCV viral load. Subjects with certain HLA alleles (A*34, B*56, DRB1*1502) have significantly lower viral load than those without these alleles (P = 0.0074, 0.0039 and 0.016, respectively) while those with HLA-B*4001 have significantly higher viral load (P = 0.0026). Furthermore, lower viral load was significantly associated with HLA-DRB1 heterozygosity in subjects with HLA-B heterozygosity (P = 0.048). CONCLUSIONS: Our data suggests a role for host immunogenetic factors in determining viral load during HCV infection. ------>tmu_sno=None ------>sno=19928 ------>authors2=Lin HH ------>authors3=Lee TD ------>authors4=Wu YF ------>authors5=Hu CT ------>authors6=Cheng ML, Lo SY ------>authors6_c= ------>authors=Wang LY ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Human leukocyte antigen phenotypes and hepatitis C viral load. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=2 |