| Lien LM |
------>authors3_c= ------>paper_class1=2 ------>Impact_Factor=None ------>paper_class3=0 ------>paper_class2=0 ------>vol= ------>confirm_bywho=hychiou ------>insert_bywho=hychiou ------>Jurnal_Rank=None ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=7 ------>paper_class2Letter=None ------>page2= ------>medlineContent= ------>unit=J0200 ------>insert_date=20081128 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=17 ------>journal_name=International Stroke Conference. San Francisco, California, USA. ------>paper_name=Circulating matrix metalloproteinase-3 but not hsCRP can predict carotid atherosclerosis in healthy volunteers. ------>confirm_date=20081211 ------>tch_id=079002 ------>pmid=19683995 ------>page1= ------>fullAbstract=BACKGROUND: Experimental data suggest that matrix metalloproteinases (MMPs) such as MMP-3 have a central role in the remodeling period after a myocardial infarction (MI). The aim of this study was to use an experimental small-animal model to investigate the fluctuation in MMP-3 levels occurring in vivo after an acute MI. METHODS: We studied 13 New Zealand white rabbits weighing between 3 and 4 kg. After anesthetizing the animals, we performed a tracheotomy and induced an acute MI in 10 of the animals by occluding the left anterior descending coronary artery for 45 minutes. The remaining 3 rabbits constituted the control group. Three hours after reperfusion, blood samples were taken for biomedical analyses. RESULTS: Three hours after the artificially induced acute MI, serum MMP-3 levels were decreased by almost 50%. Cardiac troponin I (cTnI) concentrations were increased greatly (90-fold) after MI, further validating the efficiency of our experimental in vivo model of acute MI. CONCLUSION: Combining the data, we demonstrated that acute MI caused an early reduction in MMP-3 levels. The range of MMP-3 reduction is limited compared with other factors predicting MI, such as cTnI, which increases its usefulness. We demonstrated, however, that plasma fluctuation in MMP-3 levels could be used as a supplementary independent predictor of cardiovascular events in patients with stable coronary artery disease. This acute MI model used in our controlled setting proved to be a reliable and safe method for conducting in vivo studies. ------>tmu_sno=None ------>sno=19999 ------>authors2=Hsieh YC ------>authors3=Hsieh FI ------>authors4=Bai CH ------>authors5=Chen WH ------>authors6=Chiu HC, Chiou HY, Hsu HY ------>authors6_c= ------>authors=Lien LM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=2 ------>updateTitle=Circulating matrix metalloproteinase 3 due to myocardial ischemia. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=2 |