| Lu HK |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.496 ------>paper_class3=2 ------>paper_class2=1 ------>vol=86 ------>confirm_bywho=cmshih ------>insert_bywho=wanglf ------>Jurnal_Rank=3.9 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1104 ------>medlineContent= ------>unit=E0103 ------>insert_date=20081128 ------>iam=5 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=416 ------>journal_name=Journal of Dental Research ------>paper_name=Stimulation of cells derived from nifedipine-induced gingival overgrowth with Porphyromonas gingivalis polysaccharide and interleukin-1 ------>confirm_date=20081201 ------>tch_id=062001 ------>pmid=17959904 ------>page1=1100 ------>fullAbstract=The purpose of this study was to clarify the main contributory factor of nifedipine-induced gingival overgrowth either by Porphyromonas gingivalis lipopolysaccharide (Pg-LPS) or interleukin-1beta (IL-1beta). Human gingival fibroblasts from healthy tissues and nifedipine-induced gingival overgrowth tissues were stimulated with nifedipine, IL-1beta, Escherichia coli lipopolysaccharide (Ec-LPS), and Pg-LPS, and the gene expressions were analyzed by RT-PCR. Analysis of the data showed no strong evidence of a synergistic effect of nifedipine and Pg-LPS on IL-6, connective tissue growth factor (CTGF), and type 1 collagen gene expression of either healthy cells or nifedipine-induced gingival overgrowth cells. Among the three stimulants--IL-1beta, Pg-LPS, and Ec-LPS--androgen receptor and IL-6 gene expressions in both the healthy and nifedipine-induced gingival overgrowth groups were strongly up-regulated by the presence of IL-1beta only. Furthermore, the responses to IL-1beta in the nifedipine-induced gingival overgrowth group were stronger than those of the healthy group. It can be concluded that IL-1beta is an important mediator responsible for the higher IL-6 and androgen receptor expression of nifedipine-induced gingival overgrowth cells. ------>tmu_sno=None ------>sno=20034 ------>authors2=Chou HP ------>authors3=Li CL ------>authors4=Wang MY ------>authors5=Wang LF ------>authors6= ------>authors6_c= ------>authors=Lu HK ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Stimulation of cells derived from nifedipine-induced gingival overgrowth with Porphyromonas gingivalis, lipopolysaccharide, and interleukin-1beta. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=11 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=11 |