| Tzung-Yi Lee |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.708 ------>paper_class3=2 ------>paper_class2=1 ------>vol=62 ------>confirm_bywho=chshih43 ------>insert_bywho=leecn ------>Jurnal_Rank=61.5 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=15 ------>paper_class2Letter=None ------>page2=833 ------>medlineContent= ------>unit=E0400 ------>insert_date=20081201 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=1079-2082 ------>authors_c= ------>score=475 ------>journal_name=American Journal of Health-System Pharmacists ------>paper_name=Compatibility and osmolality of inhaled N-acetylcysteine neubulizing solution with fenoterol and ipratrium. ------>confirm_date=20081215 ------>tch_id=072010 ------>pmid=15821276 ------>page1=828 ------>fullAbstract=PURPOSE: The compatibility, pH, and osmolality of N-acetylcysteine (NAC) nebulizing solution in the presence of ipratropium bromide or fenoterol hydrobromide were studied. METHODS: Portions (400 microL) of each mixture were sampled immediately upon mixing and one, two, three, four, five, six, and seven hours after mixing and assayed by high-performance liquid chromatography. Osmolality was measured by sampling 100 microL from the filling cup at a five-minute interval during nebulization and by the freezing-point-depression method. RESULTS: Adding NAC solution to fenoterol solution raised the pH from 3.20 to 7.90 and the osmolality to a mean +/- S.D. of 1400.67 +/- 4.51 mOsm/kg. Fenoterol concentrations decreased to 93.71% and NAC concentrations to 92.54% of initial concentrations after seven hours. Mixing ipratropium with NAC solution raised the pH from 3.74 to 7.95 and the osmolality to a mean +/- S.D. of 1413 +/- 11.79 mOsm/kg. The initial ipratropium concentration declined 7.39% and 10.91% one and two hours after mixing with NAC solution, respectively. CONCLUSION: NAC and ipratropium were stable in nebulizing solution within one hour of mixing. NAC and fenoterol were compatible for at least seven hours. ------>tmu_sno=None ------>sno=20291 ------>authors2=Chi-Ming, Chen ------>authors3=Chun-Nin Lee ------>authors4=Yi-Chun Chiang ------>authors5=Hsiang-Yin Chen ------>authors6= ------>authors6_c= ------>authors=Tzung-Yi Lee ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Compatibility and osmolality of inhaled N-acetylcysteine nebulizing solution with fenoterol and ipratropium. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2005 ------>submit_flag=None ------>publish_month=4 |