Chen MJ |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=1.034 ------>paper_class3=2 ------>paper_class2=1 ------>vol=23 ------>confirm_bywho=None ------>insert_bywho=wmhsu ------>Jurnal_Rank=71.1 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=566 ------>medlineContent= ------>unit=000 ------>insert_date=20081202 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=2 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=J Ocul Pharmacol Ther ------>paper_name=Comparison of the effects of latanoprost and bimatoprost on intraocular pressure in chronic angle-closure glaucoma. ------>confirm_date=None ------>tch_id=096076 ------>pmid=18001247 ------>page1=559 ------>fullAbstract=PURPOSE: The aim of this study was to compare the intraocular pressure (IOP)-lowering effect of latanoprost and bimatoprost as primary therapy in patients with chronic angle-closure glaucoma (CACG) after peripheral iridotomy. METHODS: Eighty-two (82) consecutive CACG patients with an IOP greater than 19 mmHg after a peripheral iridotomy were recruited. CACG was defined as chronic elevated IOP, glaucomatous optic neuropathy, and a corresponding visual field defect in eyes with occludable angle and peripheral anterior synechiae on gonioscopy. Patients were randomly assigned to two groups based on daily treatment with either latanoprost 0.005% or bimatoprost 0.03% in the evening for 12 weeks. The IOP was measured at 9 AM and 4 PM on the same day at baseline and also at 4, 8, and 12 weeks. Between-group differences in mean diurnal IOP and IOP reduction were analyzed. RESULTS: After 12 weeks of treatment, mean IOP for both the latanoprost and bimatoprost groups was significantly reduced when compared to the baseline value (21.6 +/- 1.9 to 16.4 +/- 2.5 mmHg and 22.1 +/- 2.0 to 16.9 +/- 2.4 mmHg, respectively; P < 0.001 for both). There was no significant difference in IOP reduction between the two treatment groups (P = 0.40). At 4 and 8 weeks, the IOP changes from baseline were statistically significant at both times for both drugs (all P < 0.001). CONCLUSIONS: Both latanoprost and bimatoprost significantly reduced IOP in CACG patients who were inadequately treated by laser peripheral iridotomy. ------>tmu_sno=None ------>sno=20406 ------>authors2=Cheng CY ------>authors3=Chou CK ------>authors4=Hsu WM ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Chen MJ ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Comparison of the effects of latanoprost and bimatoprost on intraocular pressure in chronic angle-closure glaucoma. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=6 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=12 |