| Chuang SS |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.791 ------>paper_class3=2 ------>paper_class2=1 ------>vol=53 ------>confirm_bywho=shiemin ------>insert_bywho=sschuang ------>Jurnal_Rank=15.2 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=440 ------>medlineContent= ------>unit=E0102 ------>insert_date=20081205 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Histopathology ------>paper_name=Perforation predicts poor prognosis in patients with primary intestinal diffuse large B-cell lymphoma. ------>confirm_date=20081215 ------>tch_id=094004 ------>pmid=18983608 ------>page1=432 ------>fullAbstract=AIMS: To elucidate the clinicopathological features and prognostic factors of primary intestinal diffuse large B-cell lymphoma (PI-DLBL). METHODS AND RESULTS: Archival tissues from 30 tumours were used for tissue microarray construction, immunohistochemistry and interphase fluorescence in situ hybridization for chromosomal translocation. The M:F ratio was 1.7:1, with a median age of 60 years. The ileum and ileocaecum were most frequently involved (40% each). Fourteen (47%) were at stage I(E) disease, 15 (50%) at stage II(E). Five (17%) tumours were perforated at presentation. The tumours expressed Bcl-6 (73%), MUM1 (70%), Bcl-2 (67%) and CD10 (23%). Nine (30%) were classified as germinal centre B-cell (GCB) phenotype and 21 non-GCB. Eight of 30 (27%), 7/30 (23%) and 2/29 (7%) cases were positive for rearrangements involving IGH, BCL6, and C-MYC loci, respectively, whereas all cases were negative for BCL2 and CCND1 translocation. Perforation was a poor prognostic indicator, with a hazard ratio of tumour-related death at 8.75 (P = 0.001). The differentiation antigens, GCB versus non-GCB phenotype, or lymphoma-associated translocations were of no prognostic significance. CONCLUSIONS: We found a higher rate of perforation and lower frequency of GCB phenotype in PI-DLBL in Taiwan compared with other geographical areas; perforation is a poor prognostic indicator. ------>tmu_sno=None ------>sno=20499 ------>authors2=Ye H ------>authors3=Yang SF ------>authors4=Huang WT ------>authors5=Chen HK ------>authors6=Hsieh PP, Huang WS, Chang KU, Lu CL, Du MQ. ------>authors6_c= ------>authors=Chuang SS ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Perforation predicts poor prognosis in patients with primary intestinal diffuse large B-cell lymphoma. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=10 |