| Hsing CH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.169 ------>paper_class3=2 ------>paper_class2=1 ------>vol=44 ------>confirm_bywho=jschu ------>insert_bywho=sschuang ------>Jurnal_Rank=58.6 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=228 ------>medlineContent= ------>unit=E0102 ------>insert_date=20081205 ------>iam=5 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Cytokine ------>paper_name=The distribution of interleukin-19 in healthy and neoplastic tissue. ------>confirm_date=20090318 ------>tch_id=094004 ------>pmid=18809337 ------>page1=221 ------>fullAbstract=The influence of interleukin (IL)-19, a recently discovered cytokine in the IL-10 family, on tissue is still unclear. Our aim was to determine the distribution of IL-19 expression and to delineate the cell types that express IL-19 in healthy and neoplastic tissue, because this information will significantly facilitate the exploration of its pathophysiological functions. We used tissue microarray technology and an immunohistochemical survey with an anti-IL-19 monoclonal antibody to examine the expression of IL-19 in 28 healthy and 15 neoplastic tissues. IL-19 protein was positively stained in 15 healthy tissue types and three major cell types: epithelial cells, endothelial cells, and macrophages. We also found that several types of tumor cells were positively stained for IL-19, especially in squamous cell carcinoma (SCC) of the skin, tongue, esophagus, and lung. SCC of the oral cavity expressed IL-19 mRNA and its receptors. In two cell lines derived from SCC of oral cavity tumor tissue, IL-19 specifically activated an intracellular signal and induced proliferation of the cells, which indicated that IL-19 may act in an autocrine manner in SCC tumors. This study provides important references for further investigation of the biological functions and clinical implications of IL-19 in humans. ------>tmu_sno=None ------>sno=20501 ------>authors2=Li HH ------>authors3=Hsu YH ------>authors4=Ho CL ------>authors5=Chuang SS ------>authors6=Lan KM ------>authors6_c= ------>authors=Hsing CH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=The distribution of interleukin-19 in healthy and neoplastic tissue. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=11 |