| Lin YW |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.749 ------>paper_class3=2 ------>paper_class2=1 ------>vol=377 ------>confirm_bywho=None ------>insert_bywho=d102093012 ------>Jurnal_Rank=39.1 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=7 ------>paper_class2Letter=None ------>page2=354 ------>medlineContent= ------>unit=E0123 ------>insert_date=20081205 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Biochem Biophys Res Commun. ------>paper_name=9-cis retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription. ------>confirm_date=None ------>tch_id=096053 ------>pmid=18840407 ------>page1=351 ------>fullAbstract=We previously reported that 9-cis retinoic acid (RA) treatment induced an increase in mitochondrial (mt)DNA transcription. In order to extend these results, we tested various concentrations of 9-cis RA were used to treat 143B cells. Cells with low membrane potential treated with 9-cis RA showed significantly lower amounts of RXRalpha in mitochondria. We also found lower RXRalpha levels in mtDNA-depleted cells. Treating cells with 9-cis RA significantly increased expression of ND1, ND6, and COX I RNA. However, 9-cis RA-treatment did not appear to induce any significant changes in mtDNA copy number or mitochondrial mass. This study represents that 9-cis RA increases mtDNA transcription but not mtDNA replication, and it suggests that the effects of 9-cis RA on mitochondria are mediated by RXR localization to mitochondria. In addition, this is the first report that 9-cis RA regulation of RXR mitochondrial translocation depends on mitochondrial membrane potential and ATP. ------>tmu_sno=None ------>sno=20507 ------>authors2=Lien LM ------>authors3=Yeh TS ------>authors4=Wu HM ------>authors5=Liu YL ------>authors6=Hsieh RH ------>authors6_c= ------>authors=Lin YW ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=9-cis retinoic acid induces retinoid X receptor localized to the mitochondria for mediation of mitochondrial transcription. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=2 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=10 |