| Ko SC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.719 ------>paper_class3=2 ------>paper_class2=1 ------>vol=52 ------>confirm_bywho=chshih43 ------>insert_bywho=kuochen101 ------>Jurnal_Rank=45.5 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=521 ------>medlineContent= ------>unit=E0400 ------>insert_date=20081205 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=406 ------>journal_name=Acta Anaesthesiol Scand 2008;:514-21 ------>paper_name=Effects of PEEP levels following repeated recruitment maneuvers on ventilator-induced lung injury. Acta Anaesthesiol Scand ------>confirm_date=20081215 ------>tch_id=096016 ------>pmid=18261196 ------>page1=514 ------>fullAbstract=BACKGROUND: Different levels of positive end-expiratory pressure (PEEP) with and without a recruitment maneuver (RM) may have a significant impact on ventilator-induced lung injury but this issue has not been well addressed. METHODS: Anesthetized rats received hydrochloric acid (HCl, pH 1.5) aspiration, followed by mechanical ventilation with a tidal volume of 6 ml/kg. The animals were randomized into four groups of 10 each: (1) high PEEP at 6 cm H(2)O with an RM by applying peak airway pressure at 30 cm H(2)O for 10 s every 15 min; (2) low PEEP at 2 cm H(2)O with RM; (3) high PEEP alone; and (4) low PEEP alone. RESULTS: The mean arterial pressure and the amounts of fluid infused were similar in the four groups. Application of the higher PEEP improved oxygenation compared with the lower PEEP groups (P<0.05). The lung compliance was better reserved, and the systemic cytokine responses and lung wet to dry ratio were lower in the high PEEP than in the low PEEP group for a given RM (P<0.05). CONCLUSIONS: The use of a combination of periodic RM and the higher PEEP had an additive effect in improving oxygenation and pulmonary mechanics and attenuation of inflammation. ------>tmu_sno=None ------>sno=20520 ------>authors2=Zhang H ------>authors3=Haitsma JJ ------>authors4=Cheng KC ------>authors5=Li CF ------>authors6=Slutsky AS ------>authors6_c= ------>authors=Ko SC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Effects of PEEP levels following repeated recruitment maneuvers on ventilator-induced lung injury. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=1 |