| Lei YC |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.278 ------>paper_class3=2 ------>paper_class2=1 ------>vol=59 ------>confirm_bywho=tlc ------>insert_bywho=nekota ------>Jurnal_Rank=34.0 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=26 ------>paper_class2Letter=None ------>page2=101 ------>medlineContent= ------>unit=E0121 ------>insert_date=20081205 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS ------>paper_name=Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers. ------>confirm_date=20081209 ------>tch_id=095097 ------>pmid=12160895 ------>page1=93 ------>fullAbstract=The association between metabolic polymorphisms and cigarette smoking-induced cancers has been documented. However, the role of DNA repair polymorphism in carcinogenesis is less clear. To investigate if the polymorphisms of metabolic traits and DNA repair modulate smoking-related DNA damage, we used sister chromatid exchange (SCE) as a marker of genetic damage to explore the relationship of microsomal epoxide hydrolase (mEH), glutathione S-transferase M1 (GSTM1), and X-ray cross-complementing group 1 (XRCC1) and cigarette smoking-induced SCE. Sixty-one workers without significant exposure to mutagens were recruited. Questionnaires were completed to obtain detailed occupational, smoking, and medical histories. SCE frequency in peripheral lymphocytes was determined using a standard cytogenetic assay and GSTM1, mEH (exons 3 and 4), XRCC1 (codon 399) genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism (PCR/RFLP). Smokers had higher SCE frequency than non-smokers (8.4 versus 7.1, P<0.05). Among workers who had smoked equal to or greater than 10 cigarettes each day, those with XRCC1 Arg/Gln+Gln/Gln had higher SCE frequency than those with XRCC1 Arg/Arg after adjusting for potential confounders (9.0 versus 7.9, P<0.05). The interaction of XRCC1 and cigarettes smoked per day on SCE frequency was also observed (P=0.02). There was no significant interaction between cigarettes smoked per day with GSTM1 and mEH on SCE frequency. Our results support previous epidemiological studies that XRCC1 may play a role in cigarette smoking-induced lung cancer. ------>tmu_sno=None ------>sno=20531 ------>authors2=Hwang SJ ------>authors3=Chang CC ------>authors4=Kuo HW ------>authors5=Luo JC ------>authors6=Chang MJ, Cheng TJ ------>authors6_c=??? ------>authors=Lei YC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC1 in smokers. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=1-2 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2002 ------>submit_flag=None ------>publish_month=8 |