| Liu KS |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.948 ------>paper_class3=2 ------>paper_class2=1 ------>vol=92 ------>confirm_bywho=tlc ------>insert_bywho=jitzeng ------>Jurnal_Rank=18.2 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=5 ------>paper_class2Letter=None ------>page2=715 ------>medlineContent= ------>unit=E0121 ------>insert_date=20081208 ------>iam=5 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=429 ------>journal_name=Br J Anaesth ------>paper_name=The Antinociceptive Effect of A Novel Long-acting Nalubphine Preparation ------>confirm_date=20081209 ------>tch_id=094011 ------>pmid=15003978 ------>page1=712 ------>fullAbstract=BACKGROUND: A long-acting analgesic may be particularly desirable in patients suffering from long-lasting pain. The aim of the study was to evaluate the antinociceptive effect of a novel nalbuphine preparation and to determine its duration of action. METHODS: The antinociceptive effects of i.m. nalbuphine HCl in saline and nalbuphine base in sesame oil were evaluated in rats. The in vitro drug-releasing profiles of nalbuphine HCl and base in different preparations were also evaluated. RESULTS: We found that i.m. nalbuphine HCl 25, 50 and 100 micromol kg(-1) produced dose-related antinociceptive effects with a duration of action of 1.5, 2 and 3 h, respectively. i.m. nalbuphine base 100, 200 and 400 micromol kg(-1) also produced dose-related antinociceptive effects but with longer durations of action: 27, 49 and 55 h, respectively. In vitro studies demonstrated that nalbuphine base in sesame oil had the slowest drug-releasing profile of the different preparations. CONCLUSIONS: i.m. injection of an oil formulation of nalbuphine base produced a long-lasting antinociceptive effect. ------>tmu_sno=None ------>sno=20574 ------>authors2=Hu OYP ------>authors3=Ho ST ------>authors4=Tzeng ST ------>authors5=Tzeng JI ------>authors6=Chen YW, Wang JJ ------>authors6_c= ------>authors=Liu KS ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Antinociceptive effect of a novel long-acting nalbuphine preparation. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=3 |