| Liao SC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=6.486 ------>paper_class3=2 ------>paper_class2=1 ------>vol=173 ------>confirm_bywho=chshih43 ------>insert_bywho=kuochen101 ------>Jurnal_Rank=9.9 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=6718 ------>medlineContent= ------>unit=E0400 ------>insert_date=20081209 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=J Immunology. ------>paper_name=IL-19 induced Th2 cytokines and was up-regulated in asthma patients. ------>confirm_date=20081215 ------>tch_id=096016 ------>pmid=15557163 ------>page1=6712 ------>fullAbstract=IL-19 belongs to the IL-10 family, which includes IL-10, IL-19, IL-20, IL-22, melanoma differentiation-associated gene-7 (IL-24), and AK155 (IL-26). IL-10 has been shown to inhibit allergen-induced airway hyperreactivity and inflammation. To determine whether IL-19 was also associated with asthma, we used ELISA to analyze the serum level of IL-19 in patients with asthma and found that their serum IL-19 levels were twice those of healthy controls. Patients with a high level of IL-19 also had high levels of IL-4 and IL-13. In a dust mite-induced murine model of asthma, we found that IL-19 level in asthmatic BALB/cJ mice was also twice that of healthy control mice. IL-19 transcript was also induced in the lungs of asthmatic mice. Electroporation i.m. of the IL-19 gene into healthy mice up-regulated IL-4 and IL-5, but not IL-13. However, IL-19 up-regulated IL-13 in asthmatic mice. In vitro, IL-19 induced IL-4, IL-5, IL-10, and IL-13 production by activated T cells. Activation of T cells was required for induction of IL-13 because IL-19 did not induce IL-13 production on nonstimulated T cells. Taken together, these results demonstrated that IL-19 up-regulates Th2 cytokines on activated T cells and might play an important role in the pathogenesis of asthma. ------>tmu_sno=None ------>sno=20636 ------>authors2=Cheng YC ------>authors3=Wang YC ------>authors4=Wang CW ------>authors5=Yang SM ------>authors6=Yu CK,Shieh CC, Cheng KC, Lee MF, Chiang SR, Shieh JM, Chang MS ------>authors6_c= ------>authors=Liao SC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=IL-19 induced Th2 cytokines and was up-regulated in asthma patients. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2004 ------>submit_flag=None ------>publish_month=1 |