| Chang SH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.769 ------>paper_class3=2 ------>paper_class2=1 ------>vol=47 ------>confirm_bywho=yjchen ------>insert_bywho=cmbwrlee ------>Jurnal_Rank=31.7 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1294 ------>medlineContent= ------>unit=E1400 ------>insert_date=20081212 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Dermatol. Surg ------>paper_name=The wrinkles soothing effect on the middle and lower face by intradermal injection of botulinum toxin type A ------>confirm_date=20081214 ------>tch_id=082004 ------>pmid=19126019 ------>page1=1287 ------>fullAbstract=BACKGROUND: Botulinum toxin type A (BTA) has been used on facial expressive muscles to reduce wrinkles. We assumed that intradermal injection with BTA on the middle and lower face can produce face-lifting and wrinkles-soothing effect by promoting collagen synthesis. METHODS: Nine volunteers were included to undergo intradermal injections of a total dose of 20~25 U BTA into one-half of the face, and normal saline into the other half as control. Clinical photographs were taken every 4 weeks for 16 weeks, and evaluated by a doctor blinded to the assignments. Patients graded the results of wrinkles elimination on each follow-up. Skin biopsies were taken before the treatment and 8 weeks after the injection. The specimens were assessed by a pathologist using hematoxylin and eosin stain, elastin stain, Masson trichrome stain and immunohistochemical stain with type I procollagen. RESULTS: By photographic documentation, there was no significant face-lifting effect. However, there was statistical significance in wrinkles reduction on the BTA sides compared to pre-treatment. Subjectively, six subjects noticed better wrinkles soothing effect on the BTA sides. This effect was noted as early as 4 weeks after injection, and lasted for a minimum 8 weeks. The histologic examination revealed slight neocollagen synthesis by Masson trichrome stain on both sides. CONCLUSIONS: Based on this pilot study, the face-lifting effect of intradermal injection with BTA was not conclusive. Interestingly, BTA showed moderate but significant wrinkles-soothing effect without obvious side effects on the lower face. ------>tmu_sno=None ------>sno=20767 ------>authors2=Tsai HH ------>authors3=Chen WY ------>authors4=Lee WR ------>authors5=Chen PL ------>authors6=Tsai TH ------>authors6_c= ------>authors=Chang SH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=The wrinkles soothing effect on the middle and lower face by intradermal injection of botulinum toxin type A. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=1 |