| Chen CC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=1 ------>paper_class2=1 ------>vol=26 ------>confirm_bywho=wingchan ------>insert_bywho=ed100975 ------>Jurnal_Rank=None ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=351 ------>medlineContent= ------>unit=E0119 ------>insert_date=20081224 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=447 ------>journal_name=Chang Gung Med J ------>paper_name=Short-term effect of bilateral subthalamic stimulation for advanced parkinsons disease ------>confirm_date=20081224 ------>tch_id=097094 ------>pmid=12934851 ------>page1=344 ------>fullAbstract=BACKGROUND: Subthalamic nucleus (STN) hyperactivity is a pathophysiological phenomenon of Parkinson~s disease (PD). Inhibition of this hyperactivity by chronic deep brain stimulation (DBS) can possibly reset the aberrant function of the cortico-striato-thalamal circuit and improve the parkinsonian symptoms. DBS was introduced as a safe and alternative way of performing functional stereotaxic surgery for treating PD. METHODS: Seven advanced PD patients with complicated motor fluctuations and dyskinesia were enrolled in the study. A quadripolar electrode was bilaterally installed in the STN. Patients were evaluated before and 6 months after implantation using a battery of clinical assessments, including the motor score of the unified Parkinson~s disease rating scale (UPDRS), modified Hoehn and Yahr (HY) staging, and the Schwab and England activities of daily living scale (SEADL). Preoperative baseline evaluations included both "off-medication" periods and "on-medication" periods, while postoperative evaluations included a cross-over of the above 2 periods with and without DBS. RESULTS: The motor disability, HY staging, and SEADL all significantly improved in both the off- and on-medication periods 6 months after STN DBS. Compared to the baseline off-medication score, a significant improvement was found in the UPDRS motor and other subscores including tremors, rigidity, and bradykinesia. The SEADL score showed a great improvement of 205.6%. Ballism/chorea, mood changes, and blepharospasm may have been induced by DBS. Neither serious nor permanent side effects appeared. CONCLUSIONS: Bilateral STN DBS improved the motor symptoms in advanced PD patients in both the off- and on-medication periods. They showed improvements not only in motor disabilities of tremors, rigidity, bradykinesia, and postural and gait instability, but also in levodopa-related dyskinesia and psychosis. ------>tmu_sno=None ------>sno=20957 ------>authors2=Lee ST ------>authors3=Wu T ------>authors4=Chen CJ ------>authors5=Chen MC ------>authors6=Lu CS ------>authors6_c= ------>authors=Chen CC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Short-term effect of bilateral subthalamic stimulation for advanced Parkinson~s disease. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=NULL ------>no=5 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2003 ------>submit_flag=None ------>publish_month=5 |