| Chen YA |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.085 ------>paper_class3=2 ------>paper_class2=1 ------>vol=32 ------>confirm_bywho=amel ------>insert_bywho=kyhsu ------>Jurnal_Rank=73.2 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=29 ------>paper_class2Letter=None ------>page2=154 ------>medlineContent= ------>unit=G0100 ------>insert_date=20090202 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=0253-6269 ------>authors_c=??? ------>score=500 ------>journal_name=Arch Pharm Res ------>paper_name=Pharmacokinetics of (-)-Epicatechin in Rabbits ------>confirm_date=20090316 ------>tch_id=072001 ------>pmid=19183888 ------>page1=149 ------>fullAbstract=The aim of this study was to investigate the pharmacokinetics of (-)-epicatechin (EC) in rabbits after intravenous, intraperitoneal, and oral administration. A two-compartment model was used to describe the pharmacokinetics of EC after intravenous administration. EC showed dose-independent pharmacokinetics after intravenous administration. In addition, the area under the concentration-time curve was proportional to the dose over the range 5-25 mg/kg. After intraperitoneal administration of 25 mg/kg, a high percentage of EC escaped from first-pass hepatic elimination. After oral administration of 50 mg/kg, there was a great variation in the pharmacokinetics, and the mean oral bioavailability of EC was 4%. There was no significant difference in the elimination rate constants in all treatments (p>0.05). In conclusion, after intravenous, intraperitoneal, and oral administration of EC, the EC exhibits dose-independent pharmacokinetics in rabbits. The first-pass effect did not participate in the low oral bioavailability. Base on the results of the present study, the other factors may contribute the low oral bioavailability. ------>tmu_sno=None ------>sno=21120 ------>authors2=Hsu KY ------>authors3= ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Chen YA ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Pharmacokinetics of (-)-epicatechin in rabbits. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=1 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=1 |