| Hsiu-Man Lien |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.535 ------>paper_class3=2 ------>paper_class2=1 ------>vol= ------>confirm_bywho=leehorng ------>insert_bywho=hoyuansn ------>Jurnal_Rank=16.7 ------>authors4_c=??? ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2= ------>medlineContent= ------>unit=E0310 ------>insert_date=20090305 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Evidence Based Complementary and Alternative Medicine ------>paper_name=Inhibition of anchorage-independent proliferation and G0/G1 cell cycle regulation in human colorectal carcinoma cells by 4,7-dimethoxy-5-methyl-l,3-benzodioxole isolated from the fruiting body of Antrodia camphorate ------>confirm_date=20090306 ------>tch_id=084007 ------>pmid=19293251 ------>page1= ------>fullAbstract=In this study, 4,7-dimethoxy-5-methyl-l,3-benzodioxole (SY-1) was isolated from three different sources of dried fruiting bodies of Antrodia camphorate (AC). AC is a medicinal mushroom that grows on the inner heartwood wall of Cinnamomum kanehirai Hay (Lauraceae), an endemic species that is used in Chinese medicine for its anti-tumor and immunomodulatory properties. In this study, we demonstrated that SY-1 profoundly decreased the proliferation of human colon cancer cells (COLO 205) through G0/G1 cell-cycle arrest (50-150 muM) and induction of apoptosis (>150 muM). Cell-cycle arrest induced by SY-1 was associated with a significant increase in levels of p53, p21/Cip1 and p27/Kip1, and a decrease in cyclins D1, D3 and A. In contrast, SY-1 treatment did not induce significant changes in G0/G1 phase cell-cycle regulatory proteins in normal human colonic epithelial cells (FHC). The cells were cultured in soft agar to evaluate anchorage-independent colony formation, and we found that the number of transformed colonies was significantly reduced in the SY-1-treated COLO 205 cells. These findings demonstrate for the first time that SY-1 inhibits human colon cancer cell proliferation through inhibition of cell growth and anchorage-independent colony formation in soft agar. However, the detailed mechanisms of these processes remain unclear and will require further investigation. ------>tmu_sno=None ------>sno=21166 ------>authors2=Hsiao-Wei Lin ------>authors3=Ying-Jan Wang ------>authors4=Li-Ching Chen ------>authors5=Ding-Yah Yang ------>authors6=Ya-Yun Lai5, and Yuan-Soon Ho ------>authors6_c=???, ??? ------>authors=Hsiu-Man Lien ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Inhibition of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle Regulation in Human Colorectal Carcinoma Cells by 4,7-Dimethoxy-5-methyl-l,3-benzodioxole Isolated from the Fruiting Body of Antrodia camphorate. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=1 |