| Chen LG |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.193 ------>paper_class3=2 ------>paper_class2=1 ------>vol=0 ------>confirm_bywho=amel ------>insert_bywho=crystal ------>Jurnal_Rank=37.0 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=00 ------>medlineContent= ------>unit=G0100 ------>insert_date=20090309 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Toxicology in Vitro ------>paper_name=Ellagitannins from Terminalia calamansanai Induced Apoptosis in HL-60 Cells ------>confirm_date=20090817 ------>tch_id=088003 ------>pmid=19490839 ------>page1=00 ------>fullAbstract=Terminalia calamansanai (Blanco) Rolf. (Combretaceae) is used medicinally as lithontriptic in Philippines. The 70% acetone extracts of T. calamansanai leaves inhibited the viability of human promyelocytic leukemia HL-60 cells. 1-Alpha-O-galloylpunicalagin, punicalagin, 2-O-galloylpunicalin, sanguiin H-4, and methyl gallate were the main components isolated from T. calamansanai with the IC(50) values of 65.2, 74.8, 42.2, 38.0 and >100 microM, respectively, for HL-60 cells. Apoptosis of HL-60 cells treated with 1-Alpha-O-galloylpunicalagin, punicalagin, 2-O-galloylpunicalin, and sanguiin H-4 was noted by the appearance of a sub-G(1) peak in flow cytometric analysis and DNA fragmentation by gel electrophoresis. 2-O-Galloylpunicalin and sanguiin H-4 induced a decrease of the human poly(ADP-ribose)polymerase (PARP) cleavage-related procaspase-3 and elevated activity of caspase-3 in HL-60 cells, but not normal human peripheral blood mononuclear cells (PBMCs), suggesting that both compounds may be new candidates for drug development in the prevention and treatment of cancer. ------>tmu_sno=None ------>sno=21224 ------>authors2=Huang WT ------>authors3=Lee LT ------>authors4=Wang CC ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Chen LG ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Ellagitannins from Terminalia calamansanai induced apoptosis in HL-60 cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=0 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=3 |