| Chia-Shiang Lin |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.504 ------>paper_class3=2 ------>paper_class2=1 ------>vol=32 ------>confirm_bywho=None ------>insert_bywho=enochlai49 ------>Jurnal_Rank=50.0 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=216 ------>medlineContent= ------>unit=000 ------>insert_date=20090310 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=2 ------>ISSN= ------>authors_c= ------>score=479 ------>journal_name=Regional Anesthesia and Pain Medicine ------>paper_name=Chronic intrathecal infusion of minocycline prevents the development of spinal-nerve ligation-induced pain in rat ------>confirm_date=None ------>tch_id=083041 ------>pmid=17543815 ------>page1=209 ------>fullAbstract=BACKGROUND AND OBJECTIVES: Minocycline is a second-generation tetracycline with multiple biological effects, including inhibition of microglial activation. Recently, microglial activation has been implicated in the development of nerve injury-induced neuropathic pain. In this study, the authors examined the effects of continuous intrathecal minocycline on the development of neuropathic pain and microglial activation induced by L5/6 spinal-nerve ligation in rats. METHODS: Under isoflurane anesthesia, male Sprague-Dawley rats (200-250 g) received right L5/6 spinal-nerve ligation and intrathecal catheters connected to an infusion pump. Intrathecal saline or minocycline (2 and 6 microg/h) was given continuously after surgery for 7 days (n = 8 per group). The rat right hind paw withdrawal threshold to von Frey filament stimuli and withdrawal latency to radiant heat were determined before surgery and on days 1 to 7 after surgery. Spinal microglial activation was evaluated with OX-42 immunoreactivity on day 7 after surgery. RESULTS: Spinal-nerve ligation induced mechanical allodynia and thermal hyperalgesia on the affected hind paw of saline-treated rats. Intrathecal minocycline (2 and 6 microg/h) prevented the development of mechanical allodynia and thermal hyperalgesia induced by nerve ligation. It also inhibited nerve ligation-induced microglial activation, as evidenced by decreased OX-42 staining. No obvious histopathologic change was noted after intrathecal minocycline (6 microg/h) infusion. CONCLUSIONS: In this study, the authors demonstrate the preventive effect of continuous intrathecal minocycline on the development of nociceptive behaviors induced by L5/6 spinal-nerve ligation in rats. Further studies are required to examine if continuous intrathecal minocycline could be used safely in the clinical setting. ------>tmu_sno=None ------>sno=21257 ------>authors2=Meei-Ling Twaur ------>authors3=Chien-Chuan Chen ------>authors4=Tao-Yeuan Wang ------>authors5=Chih-Fu Lin ------>authors6=Yuen-Liang Lai, Tien-Chi Hsu, Yu-Yen Pan, Chen-Hsien Yang and Jen-Kun Cheng ------>authors6_c= ------>authors=Chia-Shiang Lin ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Chronic intrathecal infusion of minocycline prevents the development of spinal-nerve ligation-induced pain in rats. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=3 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |