| KUWABARA Satoshi |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.424 ------>paper_class3=2 ------>paper_class2=1 ------>vol=26 ------>confirm_bywho=ryyuan ------>insert_bywho=b771002 ------>Jurnal_Rank=49.8 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=287 ------>medlineContent= ------>unit=E0123 ------>insert_date=20090312 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Muscle & nerve ------>paper_name=Axonal hyperpolarization associated with acute hypokalemia: multiple excitability measurements as indicators of the membrane potential of human axons ------>confirm_date=20090313 ------>tch_id=095052 ------>pmid=12210395 ------>page1=283 ------>fullAbstract=Multiple nerve excitability measurements have been proposed for clinical testing of nerve function, and an important determinant of excitability is membrane potential. We report a patient with acquired hypokalemic paralysis in whom multiple excitability indices (stimulus-response curve, strength-duration properties, threshold electrotonus, recovery cycle) were measured during and after an acute hypokalemic attack (serum K(+) level, 2.1 mEq/L and 4.5 mEq/L, respectively). During hypokalemia, there was a shift of the stimulus-response curve to the right, a decrease in strength-duration time constant, a "fanning-out" of responses during threshold electrotonus, a reduction in relative refractory period, and an increase in superexcitability; all of these indicate axonal hyperpolarization, presumably due to the K(+) equilibrium potential being more negative. These indices returned to normal 20 h later, associated with normalization of the serum K(+) level. These results demonstrate that the changes associated with hypokalemic paralysis are not confined to muscle and that axons undergo hyperpolarization in vivo. Multiple excitability measurements can be used as a tool to identify changes in membrane potential of human axons. ------>tmu_sno=None ------>sno=21400 ------>authors2=KANAI Kazuaki ------>authors3=SUNG Jia-Ying ------>authors4=OGAWARA Kazue ------>authors5=HATTORI Takamichi ------>authors6=BURKE David, BOSTOCK Hugh ------>authors6_c= ------>authors=KUWABARA Satoshi ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Axonal hyperpolarization associated with acute hypokalemia: multiple excitability measurements as indicators of the membrane potential of human axons. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2002 ------>submit_flag=None ------>publish_month=8 |