| Wu YN |
------>authors3_c=??? ------>paper_class1=2 ------>Impact_Factor=None ------>paper_class3=0 ------>paper_class2=0 ------>vol= ------>confirm_bywho=lm ------>insert_bywho=ccwu ------>Jurnal_Rank=None ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=14 ------>paper_class2Letter=None ------>page2=95 ------>medlineContent= ------>unit=E0117 ------>insert_date=20090316 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=166 ------>journal_name=???????????????????????????? ------>paper_name=???????????46,XX,SRY-Negative Man??????????????? ------>confirm_date=20090317 ------>tch_id=077009 ------>pmid=15652914 ------>page1=95 ------>fullAbstract=OBJECTIVE: To report a case of a 46,XX SRY-negative man with a male phenotype and azoospermia. DESIGN: Case report. SETTING: Molecular and Cytogenetic Unit in a University Hospital. PATIENT(S): A 35-year-old man with complete masculinization who referred to our institution because of a history of several years of infertility. INTERVENTION(S): Lymphocytic karyotype and genetic counseling. MAIN OUTCOME MEASURE(S): Peripheral blood metaphases were analyzed by standard G-banding and Q-banding. Fluorescent in situ hybridization (FISH) and polymerase chain reaction (PCR) analyses were performed. RESULT(S): Semen analysis showed azoospermia. Chromosome analysis revealed a 46,XX karyotype; molecular and cytogenetic analyses excluded the presence of SRY (the sex-determining region of the Y chromosome) gene. CONCLUSION(S): This case is one of the rare patients reported in the literature in whom testicular differentiation and a complete virilization in a 46,XX chromosomal constitution does not account for a translocation of the SRY gene to the X chromosome or to the autosomes. This finding suggests that other genes downstream from SRY, not yet identified, play an important role in sex determination. ------>tmu_sno=None ------>sno=21561 ------>authors2=Wu CC ------>authors3=Chiang HS ------>authors4= ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Wu YN ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=1 ------>updateTitle=A 46,XX SRY-negative man with complete virilization and infertility as the main anomaly. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=3 |