| Chuang SS |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.080 ------>paper_class3=2 ------>paper_class2=2 ------>vol=205 ------>confirm_bywho=jschu ------>insert_bywho=sschuang ------>Jurnal_Rank=80.3 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=287 ------>medlineContent= ------>unit=E0102 ------>insert_date=20090318 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Pathol Res Pract ------>paper_name=Lymphohistiocytic anaplastic large cell lymphoma involving skin: a diagnostic challenge. ------>confirm_date=20090318 ------>tch_id=094004 ------>pmid=19091487 ------>page1=283 ------>fullAbstract=Systemic anaplastic large cell lymphoma (ALCL) involving the skin should be differentiated from primary cutaneous CD30-positive T-cell lymphoproliferative disorders. The lymphohistiocytic variant of ALCL (LH-ALCL) is rich in reactive histiocytes with relatively few neoplastic cells, which pose a diagnostic challenge. We present a case of LH-ALCL involving skin mimicking granulomatous inflammation. A 30-year-old woman presented with cervical lymphadenopathy and multiple non-tender, non-itching, erythematous papules over the neck, chest, and abdomen. Biopsy of the cervical lymph node showed LH-ALCL with null cell phenotype. Microscopically, the cutaneous lesion was located predominately around the hair follicle, with numerous reactive histiocytes and scanty medium-sized lymphoma cells expressing CD30 and anaplastic lymphoma kinase (ALK) protein. Furthermore, an ALK gene rearrangement was demonstrated by locus-specific interphase fluorescent in situ hybridization, confirming cutaneous involvement with LH-ALCL. LH-ALCL involving the skin is a rare event, and the numerous reactive histiocytes may mask scanty tumor cells. In addition to B-and T-cell markers, (dermato) pathologists must be aware of this entity in cutaneous lymphohistiocytic proliferations and perform immunostaining for CD30 and ALK to reach a correct diagnosis. ------>tmu_sno=None ------>sno=21623 ------>authors2=Hsieh YC ------>authors3=Ye H ------>authors4=Hwang SW ------>authors5= ------>authors6= ------>authors6_c= ------>authors=Chuang SS ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Lymphohistiocytic anaplastic large cell lymphoma involving skin: a diagnostic challenge. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=4 |