| Hsiao SC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.080 ------>paper_class3=2 ------>paper_class2=2 ------>vol=205 ------>confirm_bywho=jschu ------>insert_bywho=sschuang ------>Jurnal_Rank=80.3 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=49 ------>medlineContent= ------>unit=E0102 ------>insert_date=20090318 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Pathol Res Pract ------>paper_name=EBV-associated diffuse large B-cell lymphoma in a psoriatic treated with methotrexate. ------>confirm_date=20090427 ------>tch_id=094004 ------>pmid=18951733 ------>page1=43 ------>fullAbstract=Methotrexate-associated lymphoproliferative disorder (MTX-LPD) is a lymphoid proliferation or lymphoma in a patient immunosuppressed with MTX, which is usually administered for treating autoimmune diseases. The majority of MTX-LPD cases develop in patients with rheumatoid arthritis and occasionally with psoriasis who had been treated with MTX. Here, we report on a 50-year-old Taiwanese male with severe psoriasis, who received high doses of MTX. The patient developed EBV-positive MTX-LPD at nodal and extranodal sites. The diffuse and polymorphic lymphoid infiltrate consisted predominantly of immunoblasts and plasmablasts expressing B-cell markers, CD138, Epstein-Barr virus (EBV)-LMP1, and EBNA2, and these were monotypic for kappa light chain. The tumor cells were also positive for EBV by in situ hybridization. These findings indicated a type III latency infection of EBV. The patient died of progressive disease after 19 months. A review of the previously reported cases shows that MTX-LPD, in association with psoriasis, occurs in middle-aged males. The tumors are diffuse large B-cell lymphomas with immunoblastic morphology, and frequently show plasmacytic differentiation. ------>tmu_sno=None ------>sno=21626 ------>authors2=Ichinohasama R ------>authors3=Lin SH ------>authors4=Liao YL ------>authors5=Chang ST ------>authors6=Cho CY, Chuang SS ------>authors6_c= ------>authors=Hsiao SC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=EBV-associated diffuse large B-cell lymphoma in a psoriatic treated with methotrexate. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=1 |