Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chou B-H
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------>journal_name=Phytochemistry
------>paper_name=Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor
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------>fullAbstract=A number of hydroxylated diterpenoids were obtained from the microbial transformation of isosteviol lactone (4alpha-carboxy-13alpha-hydroxy-13,16-seco-ent-19-norbeyeran-16-oic acid 13,16-lactone) (2) with Mucorrecurvatus MR 36, Aspergillusniger BCRC 31130, and Absidiapseudocylindrospora ATCC 24169. Incubation of 2 with M. recurvatus and Asp.niger led to isolation of seven known compounds (1 and 3-8). Incubation of 2 with Abs. pseudocylindrospora produced 5 and six previously unreported compounds (9-14). The structures of these isolated compounds were deduced by high-field NMR techniques ((1)H, (13)C, DEPT, COSY, NOESY, HSQC, and HMBC), and those of 9 and 11 were further confirmed by X-ray crystallographic analyses. Subsequently, the inhibitory effects on activator protein-1 (AP-1) activation in lipopolysaccharide-stimulated RAW 264.7 macrophages of all of these compounds were evaluated. Compounds 2-5, 8, 9, 11, and 12 exhibited significant inhibitory activity, while 3 was more potent than the reference compound of dexamethasone.
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------>authors2=Yang L-M
------>authors3=Chang F-L
------>authors4=Hsu F-L
------>authors5=Lo C-H
------>authors6=Lin W-K, Wang L-H, Liu P-C, Lin S-J
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------>authors=Chou B-H
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------>updateTitle=Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor.
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------>publish_year=2009
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z