| Chou BH |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.946 ------>paper_class3=2 ------>paper_class2=1 ------>vol=70 ------>confirm_bywho=amel ------>insert_bywho=shwu-lin ------>Jurnal_Rank=13.5 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=764 ------>medlineContent= ------>unit=G0100 ------>insert_date=20090326 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Phytochemistry ------>paper_name=Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor ------>confirm_date=20090925 ------>tch_id=076002 ------>pmid=19394984 ------>page1=759 ------>fullAbstract=A number of hydroxylated diterpenoids were obtained from the microbial transformation of isosteviol lactone (4alpha-carboxy-13alpha-hydroxy-13,16-seco-ent-19-norbeyeran-16-oic acid 13,16-lactone) (2) with Mucorrecurvatus MR 36, Aspergillusniger BCRC 31130, and Absidiapseudocylindrospora ATCC 24169. Incubation of 2 with M. recurvatus and Asp.niger led to isolation of seven known compounds (1 and 3-8). Incubation of 2 with Abs. pseudocylindrospora produced 5 and six previously unreported compounds (9-14). The structures of these isolated compounds were deduced by high-field NMR techniques ((1)H, (13)C, DEPT, COSY, NOESY, HSQC, and HMBC), and those of 9 and 11 were further confirmed by X-ray crystallographic analyses. Subsequently, the inhibitory effects on activator protein-1 (AP-1) activation in lipopolysaccharide-stimulated RAW 264.7 macrophages of all of these compounds were evaluated. Compounds 2-5, 8, 9, 11, and 12 exhibited significant inhibitory activity, while 3 was more potent than the reference compound of dexamethasone. ------>tmu_sno=None ------>sno=21735 ------>authors2=Yang LM ------>authors3=Chang SF ------>authors4=Lo CH ------>authors5=Lin WK ------>authors6=Wang LH, Liu PC, Lin SJ ------>authors6_c= ------>authors=Chou BH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=5 |