| Bo-Hon Chou |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.780 ------>paper_class3=2 ------>paper_class2=1 ------>vol=70 ------>confirm_bywho=wslee ------>insert_bywho=cmbsfc21 ------>Jurnal_Rank=13.2 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=22 ------>paper_class2Letter=None ------>page2=764 ------>medlineContent= ------>unit=E1300 ------>insert_date=20090327 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Phytochemistry ------>paper_name=Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor ------>confirm_date=20090701 ------>tch_id=083008 ------>pmid=19394984 ------>page1=759 ------>fullAbstract=A number of hydroxylated diterpenoids were obtained from the microbial transformation of isosteviol lactone (4alpha-carboxy-13alpha-hydroxy-13,16-seco-ent-19-norbeyeran-16-oic acid 13,16-lactone) (2) with Mucorrecurvatus MR 36, Aspergillusniger BCRC 31130, and Absidiapseudocylindrospora ATCC 24169. Incubation of 2 with M. recurvatus and Asp.niger led to isolation of seven known compounds (1 and 3-8). Incubation of 2 with Abs. pseudocylindrospora produced 5 and six previously unreported compounds (9-14). The structures of these isolated compounds were deduced by high-field NMR techniques ((1)H, (13)C, DEPT, COSY, NOESY, HSQC, and HMBC), and those of 9 and 11 were further confirmed by X-ray crystallographic analyses. Subsequently, the inhibitory effects on activator protein-1 (AP-1) activation in lipopolysaccharide-stimulated RAW 264.7 macrophages of all of these compounds were evaluated. Compounds 2-5, 8, 9, 11, and 12 exhibited significant inhibitory activity, while 3 was more potent than the reference compound of dexamethasone. ------>tmu_sno=None ------>sno=21738 ------>authors2=Li-Ming Yang ------>authors3=Shwu-Fen Chang ------>authors4=Feng-Lin Hsu ------>authors5=Chia-Hsin Lo ------>authors6=Wen-Kuang Lin, Li-Hsuan Wang, Pan-Chun Liu, Shwu-Jiuan Lin ------>authors6_c= ------>authors=Bo-Hon Chou ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Fungal transformation of isosteviol lactone and its biological evaluation for inhibiting the AP-1 transcription factor. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=6 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=4 |