| Hsuan SL |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.377 ------>paper_class3=2 ------>paper_class2=1 ------>vol=27 ------>confirm_bywho=curator ------>insert_bywho=ksyeh ------>Jurnal_Rank=1.5 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=13 ------>paper_class2Letter=None ------>page2=2929 ------>medlineContent= ------>unit=E0104 ------>insert_date=20090406 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Vaccine ------>paper_name=Efficacy of a novel Pasteurella multocida vaccine against progressive atrophic rhinitis of swine ------>confirm_date=20090610 ------>tch_id=092080 ------>pmid=19428902 ------>page1=2923 ------>fullAbstract=The efficacy of a novel vaccine composed of three short recombinant subunit Pasteurella multocida toxin (PMT) proteins in combination with a bi-valent P. multocida whole-cell bacterin (rsPMT-PM) was evaluated in field studies for prevention and control of progressive atrophic rhinitis (PAR) of swine at 15 conventional farrow-to-finish farms. Experimental piglets that were immunized twice with the rsPMT-PM vaccine developed detectable titers of neutralizing antibodies (greater than 1:8) that prevented the growth retardation and pathological lesions typically observed following challenge with authentic PMT. A total of 542 sows were vaccinated once or twice prior to parturition and serum neutralizing antibody titers were evaluated. Both single and double vaccination protocols induced neutralizing antibody titers of 1:16 or higher in 62% and 74% of sows, respectively. Notably, neither sows nor piglets at a farm experiencing a severe outbreak of PAR at the time of the vaccination trial had detectable antibody titers, but antibody titers increased significantly to 1:16 or higher in 40% of sows following double vaccination. During the year after vaccination, clinical signs of PAR decreased in fattening pigs and growth performance improved sufficiently to reduce the rearing period until marketing by 2 weeks. Collectively, these results indicate that the rsPMT-PM vaccine could be used to provide protective immunity for controlling the prevalence and severity of PAR among farm-raised swine. ------>tmu_sno=None ------>sno=21765 ------>authors2=Liao CM ------>authors3=Huang C ------>authors4=Winton JR ------>authors5=Chen ZW ------>authors6=Lee WC, Liao JW, Chen TH, Chiou CJ, Yeh KS, Chien MS ------>authors6_c= ------>authors=Hsuan SL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Efficacy of a novel Pasteurella multocida vaccine against progressive atrophic rhinitis of swine. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=3 |