| Lin SL |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.468 ------>paper_class3=2 ------>paper_class2=1 ------>vol=85 ------>confirm_bywho=wpdeng ------>insert_bywho=hhm ------>Jurnal_Rank=6.5 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=0 ------>page2=640 ------>medlineContent= ------>unit=F0700 ------>insert_date=20090428 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Int J Radiat Biol ------>paper_name=Static magnetic field attenuates mortality rate of mice by increasing the production of IL-1 receptor antagonist ------>confirm_date=20091118 ------>tch_id=084021 ------>pmid=19557603 ------>page1=633 ------>fullAbstract=PURPOSES: Disseminated intravascular coagulation (DIC) is a complex systemic thrombohemorrhagic disorder involving intravascular coagulation and hemorrhage. The aim of this study is to test whether static magnetic field (SMF) is effective in attenuating lipopolysaccharide (LPS)-induced DIC. MATERIALS AND METHODS: In vivo experiments were performed in this study using male BALB/cByJ mice. An intraperitoneal injection of 50 mg/kg LPS was shown to lead to approximately 50% mortality and this dose was used in subsequent experiments. To test the effects of SMF on the survival rate of LPS-induced animals, the mice were exposed to 0.25-T SMF for 2 h before LPS injection. In addition, the effect of a 2-h SMF treatment on the production of anti-inflammatory cytokines was evaluated. RESULTS: In the first set of experiments, we found that the survival rate was higher in the SMF-exposed group than in the sham-exposed group. The circulating platelet (PLT) counts in the SMF-exposed mice were significantly higher than in the unexposed animals. However, no significant changes in inflammatory cytokine, including tumour necrosis factor-alpha (TNF-alpha), interleukin-1alpha (IL-1alpha), interleukin-6 (IL-6) and monocyte chemotactic protein 1 (MCP-1), in plasma were found after SMF treatment. The results from the second experiment showed that the plasma levels of interleukin-1 receptor antagonist (IL-1ra) were higher in the SMF-exposed group than in the sham group. CONCLUSIONS: Exposure to an SMF increases the plasma levels of IL-1ra. This effect may inhibit the reduction in PLT in plasma, resulting in prevention in LPS induced DIC. ------>tmu_sno=None ------>sno=21819 ------>authors2=Chang WJ ------>authors3=Lin YS ------>authors4=Ou KL ------>authors5=Lin CT ------>authors6=Lin CP, Huang HM ------>authors6_c= ------>authors=Lin SL ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Static magnetic field attenuates mortality rate of mice by increasing the production of IL-1 receptor antagonist. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=7 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=1 |