Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Ho CH
------>authors3_c=
------>paper_class1=1
------>Impact_Factor=4.930
------>paper_class3=2
------>paper_class2=1
------>vol=30
------>confirm_bywho=jschu
------>insert_bywho=chencl
------>Jurnal_Rank=19.1
------>authors4_c=???
------>comm_author=
------>patent_EDate=None
------>authors5_c=
------>publish_day=1
------>paper_class2Letter=None
------>page2=1451
------>medlineContent=
------>unit=E0102
------>insert_date=20090615
------>iam=2
------>update_date=None
------>author=???
------>change_event=4
------>ISSN=
------>authors_c=???
------>score=500
------>journal_name=Carcinogenesis
------>paper_name=Decoy receptor 3, upregulated by Epstein-Barr virus latent membrane protein 1, enhances nasopharyngeal carcinoma cell migration and invasion.
------>confirm_date=20090813
------>tch_id=092004
------>pmid=19483191
------>page1=1443
------>fullAbstract=Decoy receptor 3 (DcR3), a member of tumor necrosis factor receptor superfamily, has been implicated in tumorigenesis through its abilities to modulate immune responses and induce angiogenesis. Epstein-Barr virus (EBV), a ubiquitous gamma-herpesvirus, is associated with malignancies including nasopharyngeal carcinoma (NPC). Previous studies show that DcR3 is overexpressed in EBV-positive lymphomas and Rta, an EBV transcription activator, can upregulate DcR3 in Burkitt lymphoma cell lines. However, DcR3 expression has not been demonstrated in EBV-associated NPC nor have there been any EBV latent genes linked to DcR3 upregulation. Here, we showed DcR3 was overexpressed in NPC. Higher DcR3 expression score and DcR3-positive rate were found in metastatic NPC than in primary NPC tissues, suggesting DcR3 may enhance cell metastatic potential. This hypothesis is supported by our observation that NPC HONE-1 cells overexpressing DcR3 exhibited significant higher migration and invasion abilities in vitro. We found besides Rta, EBV latent membrane protein (LMP) 1 can upregulate DcR3 via nuclear factor-kappaB and phosphatidylinositol 3-kinase-signaling events. Approximate 75% of LMP1-positive NPC tissues overexpressed DcR3, suggesting LMP1 may enhance DcR3 expression in vivo. Data herein suggested that increasing DcR3 expression by LMP1 not only helps EBV-associated cancer cells gain survival advantage by preventing host immune detection but also increases the chance of cancer metastasis by enhancing cell migration and invasion. All these DcR3-mediated events facilitate normal cells to gain cancer hallmarks.
------>tmu_sno=None
------>sno=21978
------>authors2=Chen CL
------>authors3=Lee WY
------>authors4=Chen CJ
------>authors5=
------>authors6=
------>authors6_c=
------>authors=Ho CH
------>delete_flag=0
------>SCI_JNo=None
------>authors2_c=???
------>publish_area=0
------>updateTitle=Decoy receptor 3, upregulated by Epstein-Barr virus latent membrane protein 1, enhances nasopharyngeal carcinoma cell migration and invasion.
------>language=2
------>check_flag=None
------>submit_date=None
------>country=None
------>no=8
------>patent_SDate=None
------>update_bywho=None
------>publish_year=2009
------>submit_flag=None
------>publish_month=8
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z