| Wu JY |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=0.663 ------>paper_class3=2 ------>paper_class2=3 ------>vol= ------>confirm_bywho=None ------>insert_bywho=hsuan ------>Jurnal_Rank=90.0 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2= ------>medlineContent= ------>unit=E0105 ------>insert_date=20090707 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Adv Exp Med Biol ------>paper_name=Mechanism of neuroprotective function of taurine ------>confirm_date=None ------>tch_id=084005 ------>pmid=19239147 ------>page1= ------>fullAbstract=Taurine has potent protective function against glutamate-induced neuronal injury presumably through its function in regulation of intracellular free calcium level, [Ca2+]i. In this communication, we report that taurine exerts its protective function through one or more of the following mechanisms: 1. Inhibition of glutamate-induced calcium influx through L-, N- and P/Q-type voltage-gated calcium channels and NMDA receptor calcium channel; 2. Attenuation of glutamate-induced membrane depolarization; 3. Prevention of glutamate-induced apoptosis via preventing glutamate-mediated down-regulation of Bcl-2; 4. Prevention of cleavage of Bcl-2 by calpain. This action of taurine is due to its inhibition on glutamate induced calpain activation. Based on these observations, we propose that taurine protects neurons against glutamate-induced neurotoxicity in part, by preventing glutamate-induced membrane depolarization, elevation of [Ca2+]i, activation of calpain, reduction of Bcl-2 and apoptosis. ------>tmu_sno=None ------>sno=22017 ------>authors2=Wu H ------>authors3=Jin Y ------>authors4=Wei J ------>authors5=Sha D ------>authors6=Prentice H, Lee HH, Lin CH, Lee YH, Yang LL ------>authors6_c= ------>authors=Wu JY ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Mechanism of neuroprotective function of taurine. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=1 |