Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Chen LC
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------>journal_name=Journal of Agricultural and Food Chemistry
------>paper_name=agnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1.
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------>fullAbstract=Previously, we demonstrated that magnolol isolated from the bark of Magnolia officinalis has anticancer activity in colon, hepatoma, and leukemia cell lines. In this study, we show that magnolol concentration dependently (0-40 muM) decreased the cell number in a cultured human glioblastoma cancer cell line (U373) and arrested the cells at the G0/G1 phase of the cell cycle. Magnolol treatment decreased the protein levels of cyclins A and D1 and increased p21/Cip1, but not cyclins B and D3, cyclin-dependent kinase (CDK)2, CDK4, CDC25C, Weel, p27/Kip1, and p53. The CDK2-p21/Cip1 complex was increased, and the CDK2 kinase activity was decreased in the magnolol-treated U373. Pretreatment of U373 with p21/Cip1 specific antisense oligodeoxynucleotide prevented the magnolol-induced increase of p21/Cip1 protein levels and the decrease of DNA synthesis. Magnolol at a concentration of 100 muM induced DNA fragmentation in U373. Our findings suggest the potential applications of magnolol in the treatment of human brain cancers.
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------>authors2=Liu YC
------>authors3=Liang YC
------>authors4=Ho YS
------>authors5=Lee WS
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------>authors=Chen LC
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------>updateTitle=Magnolol Inhibits Human Glioblastoma Cell Proliferation through Upregulation of p21/Cip1.
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------>publish_year=2009
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------>publish_month=8
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z