Chen LC |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.562 ------>paper_class3=2 ------>paper_class2=1 ------>vol= ------>confirm_bywho=wslee ------>insert_bywho=wslee ------>Jurnal_Rank=5.7 ------>authors4_c=??? ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2= ------>medlineContent= ------>unit=E1300 ------>insert_date=20090818 ------>iam=5 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=485 ------>journal_name=Journal of Agricultural and Food Chemistry ------>paper_name=agnolol inhibits human glioblastoma cell proliferation through upregulation of p21/Cip1. ------>confirm_date=20090818 ------>tch_id=086001 ------>pmid=19645506 ------>page1= ------>fullAbstract=Previously, we demonstrated that magnolol isolated from the bark of Magnolia officinalis has anticancer activity in colon, hepatoma, and leukemia cell lines. In this study, we show that magnolol concentration dependently (0-40 muM) decreased the cell number in a cultured human glioblastoma cancer cell line (U373) and arrested the cells at the G0/G1 phase of the cell cycle. Magnolol treatment decreased the protein levels of cyclins A and D1 and increased p21/Cip1, but not cyclins B and D3, cyclin-dependent kinase (CDK)2, CDK4, CDC25C, Weel, p27/Kip1, and p53. The CDK2-p21/Cip1 complex was increased, and the CDK2 kinase activity was decreased in the magnolol-treated U373. Pretreatment of U373 with p21/Cip1 specific antisense oligodeoxynucleotide prevented the magnolol-induced increase of p21/Cip1 protein levels and the decrease of DNA synthesis. Magnolol at a concentration of 100 muM induced DNA fragmentation in U373. Our findings suggest the potential applications of magnolol in the treatment of human brain cancers. ------>tmu_sno=None ------>sno=22108 ------>authors2=Liu YC ------>authors3=Liang YC ------>authors4=Ho YS ------>authors5=Lee WS ------>authors6= ------>authors6_c= ------>authors=Chen LC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Magnolol Inhibits Human Glioblastoma Cell Proliferation through Upregulation of p21/Cip1. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=8 |