| C.K. Chao, L.L. Yu, L.L. Su, C.M. Liu, T.H. Yang, C.M. Chen |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=2 ------>paper_class2=1 ------>vol=50(II) ------>confirm_bywho=kyhsu ------>insert_bywho=pcmc ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=640 ------>medlineContent= ------>unit=G0100 ------>insert_date=20000810 ------>iam=7 ------>update_date= ------>author=??? ------>change_event=5 ------>ISSN=None ------>authors_c=None ------>score=500 ------>journal_name=ArzneimForsch/Drug Res. ------>paper_name=Bioequivalence study of tramadol by intramuscular administration in healthy volunteers ------>confirm_date=20010207 ------>tch_id=055001 ------>pmid=10965421 ------>page1=636 ------>fullAbstract=Tramadol hydrochloride (CAS 36282-47-0) is a centrally acting analgesic agent binding to mu opiate receptors. The bioavailability of a new tramadol hydrochloride injection (Limadol) was compared with a commercially available reference product by intramuscular administration in twelve healthy Chinese male volunteers by a standard two-way cross-over trial. Each volunteer received a single 100 mg injection of tramadol HCl in each phase. The bioavailability was compared using the area under the plasma concentration-time curve from time 0 to 30 h (AUC0-30), the area under the plasma concentration-time curve from time 0 to infinity (AUC0-infinity), peak plasma concentration (Cmax), and time to reach peak plasma concentration (Tmax). No statistically significant difference was observed between the Tmax, Cmax, AUC0-30 and AUC0-infinity of the two preparations. It is concluded that test and reference formulations of tramadol hydrochloride are bioequivalent for both the extent and rate of absorption after a single intramuscular injection. ------>tmu_sno=None ------>sno=2218 ------>authors2=None ------>authors3=None ------>authors4=None ------>authors5=None ------>authors6=None ------>authors6_c=None ------>authors=C.K. Chao, L.L. Yu, L.L. Su, C.M. Liu, T.H. Yang, C.M. Chen ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=Bioequivalence study of tramadol by intramuscular administration in healthy volunteers. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no=7 ------>patent_SDate=None ------>update_bywho= ------>publish_year=2000 ------>submit_flag= ------>publish_month=None |