| Tsai YC |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=2.583 ------>paper_class3=2 ------>paper_class2=1 ------>vol=78 ------>confirm_bywho=sylin ------>insert_bywho=sunpowerhu ------>Jurnal_Rank=40.2 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1397 ------>medlineContent= ------>unit=E0125 ------>insert_date=20090918 ------>iam=4 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Life Sci ------>paper_name=Stereoselective effects of 3-hydroxybutyrate on glucose utilization of rat cardiomyocytes ------>confirm_date=20090918 ------>tch_id=098012 ------>pmid=16225892 ------>page1=1385 ------>fullAbstract=In researches of ketone bodies, D-3-hydroxybutyrate (D-3HB) is usually the major one which has been investigated; in contrast, little attention has been paid to L-3-hydroxybutyrate (L-3HB), because of its presence in trace amounts, its dubious metabolism, and a lack of knowledge about its sources. In the present study we determined the distributions of enantiomers of 3-hydroxybutyrate (3HB) in rat brain, liver, heart, and kidney homogenates, and we found the heart homogenate contained an enriched amount of L-3HB (37.67 microM/mg protein) which generated a significant ratio of 66/34 (D/L). The ratio was altered to be 87/13 in the diabetic rat heart homogenate. We subsequently found this changed ratio of D/L-3HB may contribute to reduce glucose utilization in cardiomyocytes. Glucose utilization by cardiomyocytes with 5 mM of D-3HB was decreased to 61% of the control, but no interference was observed when D-3HB was replaced with L-3HB, suggesting L-3HB is not utilized for the energy fuel as other ketone bodies are. In addition, the reduced glucose utilization caused by D-3HB gradually recovered in a dose-dependent manner with administration of additional L-3HB. The results gave the necessity of taking L-3HB together with D-3HB into account with regard to glucose utilization, and L-3HB may be a helpful substrate for improving inhibited cardiac pyruvate oxidation caused by hyperketonemia. ------>tmu_sno=None ------>sno=22198 ------>authors2=Chou YC ------>authors3=Wu AB ------>authors4=Hu CM ------>authors5=Chen CY ------>authors6=Chen FA, Lee JA ------>authors6_c= ------>authors=Tsai YC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Stereoselective effects of 3-hydroxybutyrate on glucose utilization of rat cardiomyocytes. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2006 ------>submit_flag=None ------>publish_month=1 |