Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Hu CM
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------>journal_name=Diabetes
------>paper_name=Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice
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------>fullAbstract=Heme oxygenase-1 (HO-1) is an enzyme with potent immunoregulatory capacity. To evaluate the effect of HO-1 on autoimmune diabetes, female NOD mice at 9 weeks of age received a single intravenous injection of a recombinant adeno-associated virus bearing HO-1 gene (AAV-HO-1; 0.5 x 10(10)-2.5 x 10(10) viruses/mouse). In a dose-dependent manner, HO-1 transduction reduced destructive insulitis and the incidence of overt diabetes examined over a 15-week period. HO-1-mediated protection was associated with a lower type 1 T-helper cell (Th1)-mediated response. Adaptive transfer experiments in NOD.scid mice demonstrated that splenocytes isolated from AAV-HO-1-treated mice were less diabetogenic. Flow cytometry analysis revealed no significant difference in the percentages of CD4(+)CD25(+) regulatory T-cells between saline-treated and AAV-HO-1-treated groups. However, the CD11c(+) major histocompatibility complex II(+) dendritic cell population was much lower in the AAV-HO-1-treated group. A similar protective effect against diabetes was observed in NOD mice subjected to carbon monoxide (CO) gas (250 ppm CO for 2 h, twice per week). These data suggest that HO-1 slows the progression to overt diabetes in pre-diabetic NOD mice by downregulating the phenotypic maturity of dendritic cells and Th1 effector function. CO appears to mediate at least partly the beneficial effect of HO-1 in this disease setting.
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------>authors2=Lin HH
------>authors3=Chiang MT
------>authors4=Chang PF
------>authors5=Chau LY
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------>authors=Hu CM
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------>updateTitle=Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice.
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------>publish_year=2007
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z