Hu CM |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=8.398 ------>paper_class3=2 ------>paper_class2=1 ------>vol=56 ------>confirm_bywho=sylin ------>insert_bywho=sunpowerhu ------>Jurnal_Rank=4.3 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=1247 ------>medlineContent= ------>unit=E0125 ------>insert_date=20090918 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Diabetes ------>paper_name=Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice ------>confirm_date=20090918 ------>tch_id=098012 ------>pmid=17303808 ------>page1=1240 ------>fullAbstract=Heme oxygenase-1 (HO-1) is an enzyme with potent immunoregulatory capacity. To evaluate the effect of HO-1 on autoimmune diabetes, female NOD mice at 9 weeks of age received a single intravenous injection of a recombinant adeno-associated virus bearing HO-1 gene (AAV-HO-1; 0.5 x 10(10)-2.5 x 10(10) viruses/mouse). In a dose-dependent manner, HO-1 transduction reduced destructive insulitis and the incidence of overt diabetes examined over a 15-week period. HO-1-mediated protection was associated with a lower type 1 T-helper cell (Th1)-mediated response. Adaptive transfer experiments in NOD.scid mice demonstrated that splenocytes isolated from AAV-HO-1-treated mice were less diabetogenic. Flow cytometry analysis revealed no significant difference in the percentages of CD4(+)CD25(+) regulatory T-cells between saline-treated and AAV-HO-1-treated groups. However, the CD11c(+) major histocompatibility complex II(+) dendritic cell population was much lower in the AAV-HO-1-treated group. A similar protective effect against diabetes was observed in NOD mice subjected to carbon monoxide (CO) gas (250 ppm CO for 2 h, twice per week). These data suggest that HO-1 slows the progression to overt diabetes in pre-diabetic NOD mice by downregulating the phenotypic maturity of dendritic cells and Th1 effector function. CO appears to mediate at least partly the beneficial effect of HO-1 in this disease setting. ------>tmu_sno=None ------>sno=22199 ------>authors2=Lin HH ------>authors3=Chiang MT ------>authors4=Chang PF ------>authors5=Chau LY ------>authors6= ------>authors6_c= ------>authors=Hu CM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Systemic expression of heme oxygenase-1 ameliorates type 1 diabetes in NOD mice. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2007 ------>submit_flag=None ------>publish_month=1 |