| Tze-Wen Chunga |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.061 ------>paper_class3=2 ------>paper_class2=1 ------>vol=00 ------>confirm_bywho=wpdeng ------>insert_bywho=tonyliu ------>Jurnal_Rank=30.6 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=0 ------>medlineContent= ------>unit=F0700 ------>insert_date=20090924 ------>iam=3 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=International Journal of Pharmaceutics (in press) ------>paper_name=Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network ------>confirm_date=20090925 ------>tch_id=090026 ------>pmid=19666095 ------>page1=0 ------>fullAbstract=This study investigates in vitro the drug delivery characteristics of new thermo-sensitive gels, P-CS/GA gels, in which a chitosan (CS) network is crosslinked with various concentrations of glutaraldehyde (GA) that interpenetrates Poloxamer (P) gels. The results indicate that the swelling ratios of all P-CS/GA gels are markedly superior to those of non-swelling P and P-CS gels. For example, P-CS/GA (0.1 wt.%) gels have swelling ratios of 13.2+/-1.0, which are maintained for approximately 18 h in water at 37 degrees C. In vitro releases of 5-FU from P-CS/GA (0.1 wt.%) gels had significantly lower initial burst release (P<0.01) and lasted much longer than those from gels without a CS network. For example, the duration of release of 5-FU was in a significantly sustained manner for up to 52 h, which was about 10 times or longer than the period of delivery using P or P-CS gels. The release of drugs from gels with an interpenetrating CS network could be modeled by Fickian diffusion; the characteristic constant ~k~ of drug-gel systems decreased as increasing GA concentrations in the P-CS/GA gels, and increasing the viscosities of the P, P-CS and P-CS/GA solutions. ------>tmu_sno=None ------>sno=22286 ------>authors2=Shyr-Yi Lin ------>authors3=Der-Zen Liu ------>authors4=Yu-Chang Tyan ------>authors5=Juin-Sen Yang ------>authors6= ------>authors6_c= ------>authors=Tze-Wen Chunga ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Sustained release of 5-FU from Poloxamer gels interpenetrated by crosslinking chitosan network. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=1 |