| Li-Ping Tseng |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=1.802 ------>paper_class3=2 ------>paper_class2=1 ------>vol=00 ------>confirm_bywho=wpdeng ------>insert_bywho=tonyliu ------>Jurnal_Rank=11.2 ------>authors4_c= ------>comm_author=1 ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=0 ------>medlineContent= ------>unit=F0700 ------>insert_date=20090924 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=The Veterinary Journal (in press) ------>paper_name=The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease ------>confirm_date=20090925 ------>tch_id=090026 ------>pmid=19570697 ------>page1=0 ------>fullAbstract=The adjuvant effect of liposomes formulated with three phospholipids including phosphatidylcholine-liposomes (PC-Lip), phosphatidylserine-liposomes (PS-Lip), and stearylamine-liposomes (SA-Lip) was compared with virus alone using inactivated Newcastle disease virus (NDV) as a model antigen. The difference in adjuvanticity was evaluated using the haemagglutination-inhibition (HI) test, enzyme-linked immunosorbent assay, and a challenge study following intranasal inoculation of specific pathogen-free chickens. After two inoculations, a liposomal vaccine consisting of NDV in PC-Lip resulted in a significant increase in HI titre, up to 32-fold higher than a vaccine containing virus alone and 320-fold higher than a vaccine containing NDV in SA-Lip. PC-Lip also elicited a significant mucosal secretary immunoglobulin A response (P<0.05) in tracheal lavages and a serum IgG response (P<0.05). In response to viral challenge, all control animals died, whereas 90% of animals which received PC-Lip survived. The results suggest that PC-Lip may be suitable as an adjuvant for mucosal vaccination against NDV in chickens. ------>tmu_sno=None ------>sno=22295 ------>authors2=Hong-Jen Liang ------>authors3=Ming-Chung Deng ------>authors4=Kuo-Ming Lee ------>authors5=Ryh-Nan Pan ------>authors6=Jen-Chang Yang, Yi-You Huang, Der-Zen Liu ------>authors6_c= ------>authors=Li-Ping Tseng ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=The influence of liposomal adjuvant on intranasal vaccination of chickens against Newcastle disease. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=1 |