| Seow KM |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.954 ------>paper_class3=2 ------>paper_class2=1 ------>vol= ------>confirm_bywho=1 ------>insert_bywho=m001015 ------>Jurnal_Rank=18.0 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2= ------>medlineContent= ------>unit=E0111 ------>insert_date=20090928 ------>iam=5 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Reproductive BioMedicine Onlin ------>paper_name=Omental fat expression of adiponectin and adiponectin receptors in non-obese women with PCOS:a preliminary study ------>confirm_date=None ------>tch_id=092060 ------>pmid=19909601 ------>page1= ------>fullAbstract=Adiponectin is regarded as a possible link between adiposity and insulin resistance. The aim of the study was to determine adipose levels of mRNA for adiponectin and adiponectin receptors (AdipoR) in non-obese women with polycystic ovary syndrome (PCOS), and to assess whether the cytokine and receptors are related to insulin resistance in PCOS. Adipose tissue obtained from eight non-obese women with PCOS [body mass index (BMI) <27 kg/m(2) as cut-off point] was analysed. Levels of mRNA for adiponectin, AdipoR1 and 2 were quantified using the semi-quantitative reverse transcriptase-polymerase chain reaction. Eight non-obese, age- and BMI-matched healthy women served as controls. The level of adiponectin mRNA in non-obese women with PCOS were lower than in controls, but the difference was not statistically significant. However, AdipoR1 and 2 mRNA levels in non-obese women with PCOS were significantly lower than in controls. There was a significant negative correlation between 2 h insulin levels and AdipoR1 or AdipoR2 mRNA levels in non-obese women with PCOS ( r = 0.45 and 0.52 respectively, P < 0.05). The present study demonstrates that adiponectin receptor expression is down-regulated by hyperinsulinaemia in non-obese women with PCOS, resulting in adiponectin resistance. ------>tmu_sno=None ------>sno=22363 ------>authors2=Tsai YL ------>authors3=Juan CC ------>authors4=Lin YH ------>authors5=Hwang JL ------>authors6=Ho LT ------>authors6_c=??? ------>authors=Seow KM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Omental fat expression of adiponectin and adiponectin receptors in non-obese women with PCOS: a preliminary study. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=1 |