| Liu IM |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.202 ------>paper_class3=2 ------>paper_class2=1 ------>vol=89 ------>confirm_bywho=shtsai ------>insert_bywho=cck.ns ------>Jurnal_Rank=42.6 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2=300 ------>medlineContent= ------>unit=J0600 ------>insert_date=20091003 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=International Journal of Experimental Pathology ------>paper_name=Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats. ------>confirm_date=20091005 ------>tch_id=093088 ------>pmid=18715473 ------>page1=292 ------>fullAbstract=The role of hyperglycaemia in the pathogenesis of hypotension in diabetic disorders was investigated using the changes in cardiac M(2)-muscarinic receptor (M(2)-mAChR) gene expression in type-1-like diabetic rats and cultured cardiomyocytes. Blood pressure was markedly decreased in diabetic rats following the intravenous injection of streptozotocin (STZ) for 8 weeks. Also, the baroreflex sensitivity (Delta HR/Delta BP), as measured by the changes in heart rate (Delta HR) and mean blood pressure (Delta BP) 1 min after the intravenous injection of phenylephrine (10 microg/kg), was significantly increased. Arecaidine propargyl ester (APE), a M(2)-mAChR agonist produced a marked reduction in heart rate in these diabetic rats. Normalization of plasma glucose in diabetic rats using insulin (0.5 IU) or phlorizin (1 mg/kg) injection attenuated the blood pressure reduction and reversed the mRNA and protein levels of cardiac M(2)-mAChR. A high concentration of glucose (20 mmol/l) directly influenced the increase in gene expression of M(2)-mAChR in the H9c2 cardiac cell line. Hyperglycaemia induced an increase in cardiac M(2)-mAChR gene expression, suggesting a role in the pathogenesis of hypotension in diabetic disorders. ------>tmu_sno=None ------>sno=22413 ------>authors2=Chang CK ------>authors3=Juang SW ------>authors4=Kou DH ------>authors5=Tong YC ------>authors6=Cheng KC, Cheng JT ------>authors6_c=???, ??? ------>authors=Liu IM ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=4 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=8 |