| Wang MH |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.200 ------>paper_class3=2 ------>paper_class2=1 ------>vol=443 ------>confirm_bywho=shtsai ------>insert_bywho=cck.ns ------>Jurnal_Rank=63.5 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2=212 ------>medlineContent= ------>unit=J0600 ------>insert_date=20091003 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=454 ------>journal_name=Neuroscience Letters ------>paper_name=Activation of opioid?-receptor by sinomenine in cell and mice. ------>confirm_date=20091005 ------>tch_id=093088 ------>pmid=18692550 ------>page1=209 ------>fullAbstract=Sinomenine, one of the alkaloids extracted from roots or stems of Sinomenium acutum, is documented to show antinociceptive action but the action mechanism is still unclear. The present study was aimed to investigate the effect of sinomenine on opioid mu-receptor (OMR). In Chinese Hamster Ovary (CHO) cell transfected with OMR, the binding of [(3)H]naloxone was displaced by sinomenine in a concentration-dependent manner. This compound also raised the phosphorylation of OMR in these cells. In a tail-flick test, sinomenine produced dose-dependent antinociception in mice, which was dose-dependently inhibited by pretreatment of naloxonazine, a selective OMR antagonist. Long-term pretreatment with sinomenine may delay the analgesic tolerance of morphine. The obtained results suggest that sinomenine has an ability to activate OMR, implicating the potential of sinomenine to be applied in clinic. ------>tmu_sno=None ------>sno=22416 ------>authors2=Chang CK ------>authors3=Cheng JH ------>authors4=Wu HT ------>authors5=Li YX ------>authors6=Cheng JT ------>authors6_c=??? ------>authors=Wang MH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=Activation of opioid mu-receptor by sinomenine in cell and mice. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=3 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2008 ------>submit_flag=None ------>publish_month=10 |