| Yeh CH |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=2.648 ------>paper_class3=2 ------>paper_class2=1 ------>vol=382 ------>confirm_bywho=shtsai ------>insert_bywho=cck.ns ------>Jurnal_Rank=40.0 ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2=297 ------>medlineContent= ------>unit=J0600 ------>insert_date=20091003 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c=??? ------>score=500 ------>journal_name=Biochemical and Biophysical Research Communications ------>paper_name=The antioxidative effect of bone morphogenetic protein-7 against high glucose-induced oxidative stress in mesangial cells. ------>confirm_date=20091005 ------>tch_id=093088 ------>pmid=19275892 ------>page1=292 ------>fullAbstract=Bone morphogenetic protein-7 (BMP-7) protects kidneys from diabetic nephropathy (DN), and high glucose (HG)-induced oxidative stress is involved in DN. We investigated the antioxidative ability of BMP-7 using HG-treated mesangial cells. We treated rat mesangial cells (RMCs) with recombinant human BMP-7 (rhBMP-7) and examined changes in reactive oxygen species (ROS) levels and intracellular signals in response to HG-induced oxidative stress. rhBMP-7 decreased the level of ROS in HG-treated RMCs. In contrast, lowering endogenous BMP-7 by siRNA or BMP receptor II (BMP-RII) by anti-BMP-RII antibodies increased the level of ROS in HG-treated RMCs. rhBMP-7 increased Smad-1,5,8 phosphorylation, decreased PKCzeta and c-Jun N-terminal kinase (JNK) phosphorylation, and decreased fibronectin and collagen IV synthesis in HG-treated RMCs. In conclusion, we found that BMP-7 could protect mesangial cells from HG-induced oxidative stress by activating BMP-RII. The antioxidative activity of BMP-7 was primarily due to inhibition of PKCzeta, JNK phosphorylation, and c-jun activation. ------>tmu_sno=None ------>sno=22420 ------>authors2=Chang CK ------>authors3=Cheng MF ------>authors4=Lin HJ ------>authors5=Cheng JT ------>authors6= ------>authors6_c= ------>authors=Yeh CH ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=??? ------>publish_area=0 ------>updateTitle=The antioxidative effect of bone morphogenetic protein-7 against high glucose-induced oxidative stress in mesangial cells. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=2 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=5 |