| Yeh CT |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=3.504 ------>paper_class3=2 ------>paper_class2=1 ------>vol=285 ------>confirm_bywho=ncchang ------>insert_bywho=gminlai ------>Jurnal_Rank=36.2 ------>authors4_c=??? ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2=79 ------>medlineContent= ------>unit=E0109 ------>insert_date=20091014 ------>iam=7 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN=0304-3835 ------>authors_c=??? ------>score=500 ------>journal_name=Cancer Letters ------>paper_name=Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells ------>confirm_date=20091014 ------>tch_id=097095 ------>pmid=19477064 ------>page1=73 ------>fullAbstract=Five lanostane (2, 3, 4, 6 and 8) and three ergostane-type (1, 5 and 7) triterpenes isolated from the fruiting bodies of Antrodia camphorata were evaluated for their in vitro cytotoxic data against various cancer cell types. The three zhankuic acids, 1, 5 and 7 displayed the most potent cytotoxic effect with an IC(50) value of 22.3-75.0microM. The compound 3 was selectively cytotoxic in three colon cancer cell lines (HT-29, HCT-116 and SW-480) and a breast cancer model (MDA-MB-231), whereas 8 only showed its cytotoxicity against MDA-MB-231. None of these isolates was toxic to mammary epithelial (MCF10A) and primary foreskin fibroblast (HS68) cells, two human normal cell lines. The compounds 1, 5 and 7 were also demonstrated to induce apoptosis in HT-29 and SW-480 cells, as confirmed by sub-G1 cell cycle arrest. In HT-29 cells, the expression of apoptosis-associated proteins poly-(ADP-ribose) polymerase cleavage, Bcl-2 and procaspase-3 were suppressed by compounds 1, 5 and 7. A mixture containing 4microM each of compounds 1, 5 and 7 also showed a synergistic cytotoxic effect in HT-29 cells. ------>tmu_sno=None ------>sno=22638 ------>authors2=Rao YK ------>authors3=Yao CJ ------>authors4=Yeh CF ------>authors5=Li CH ------>authors6=Chuang SE, Luong HT, Lai GM, Tzeng YM ------>authors6_c=???, Luong HT, ???, ??? ------>authors=Yeh CT ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=Rao YK ------>publish_area=0 ------>updateTitle=Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=2009 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=10 |