| Lai CC |
------>authors3_c=??? ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=1 ------>paper_class2=1 ------>vol=6 ------>confirm_bywho=shtsai ------>insert_bywho=lupai ------>Jurnal_Rank=None ------>authors4_c=??? ------>comm_author= ------>patent_EDate=None ------>authors5_c=??? ------>publish_day=1 ------>paper_class2Letter=None ------>page2=184 ------>medlineContent= ------>unit=J0600 ------>insert_date=20091015 ------>iam=2 ------>update_date=None ------>author=?? ------>change_event=4 ------>ISSN=1810-2549 ------>authors_c=??? ------>score=76 ------>journal_name=?????? ------>paper_name=??1986-2007??????????? ------>confirm_date=20091015 ------>tch_id=089069 ------>pmid=19256285 ------>page1=174 ------>fullAbstract=BACKGROUND: The global HIV/AIDS epidemic consists of a number of regional epidemics caused by different HIV-1 subtypes prevailing in different regions. OBJECTIVES: To study changes in genetic diversity of HIV-1 strains isolated in the Czech Republic (CR) over a more than twenty-year period (1986-2007). STUDY DESIGN: HIV-1 strains isolated in CR from 1986 to 2007 were subtyped by pol gene sequencing followed by phylogenetic analysis. The role of HIV-1 subtyping in molecular epidemiology was considered. RESULTS: Awide range of HIV-1 subtypes were found, with subtype B, into which 76.6% of 534 HIV-1 isolates were classified, being predominant during the whole study period. An increasing number of non-B subtypes A1, C, D, F1, G and some recombinant forms (CRF 01_AE, CRF 02_AG and CRF 06_cpx) were identified after 1990. CONCLUSIONS: The absolute predominance of subtype B among HIV-1 strains in the Czech Republic ended in 1991 when different non-B subtypes had been introduced into the country. The East-West migration is responsible for the introduction of HIV-1 subtypes prevalent in Eastern European and some Asian countries. Genetic analysis of HIV-1 isolates from a given region can be helpful in tracing the course of the HIV/AIDS epidemic. ------>tmu_sno=None ------>sno=22664 ------>authors2=Pai L ------>authors3=Tsai SH ------>authors4=Chien WC ------>authors5=Chang WT ------>authors6=Lin CH, Hung YC ------>authors6_c=???? ??? ------>authors=Lai CC ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=? ? ------>publish_area=0 ------>updateTitle=A study of HIV-1 genetic diversity in the Czech Republic: 1986-2007. ------>language=1 ------>check_flag=None ------>submit_date=None ------>country=NULL ------>no=3 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=6 |