Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Lin HC
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------>journal_name=Neurology
------>paper_name=Herpes Zoster Ophthalmicus and the Risk of Stroke: A Population-Based Follow-Up Study
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------>fullAbstract=BACKGROUND AND PURPOSE: Varicella zoster virus-induced vasculopathy and postherpes zoster attack stroke syndromes have been reported previously; nevertheless, data regarding the exact prevalence and risk of stroke occurring postherpes zoster attack are still lacking. This study aims to investigate the frequency and risk of stroke after a herpes zoster attack using a nationwide, population-based study of a retrospective cohort design. Method- A total of 7760 patients who had received treatment for herpes zoster between 1997 and 2001 were included and matched with 23 280 randomly selected subjects. A 1-year stroke-free survival rate was then estimated using the Kaplan-Meier method. After adjusting for potential confounders, Cox proportional hazard regressions were carried out to compute the adjusted 1-year survival rate. RESULTS: Of the sampled patients, 439 patients (1.41%) developed strokes within the 1-year follow-up period, that is, 133 individuals (1.71% of the patients with herpes zoster) from the study cohort and 306 individuals (1.31% of patients in the comparison cohort) from the comparison cohort. The log rank test indicated that patients with herpes zoster had significantly lower 1-year stroke-free survival rates than the control (P<0.001). The adjusted hazard ratios of stroke after herpes zoster and herpes zoster ophthalmicus during the 1-year follow-up period were 1.31 and 4.28, respectively. CONCLUSIONS: The risk for stroke increased after a zoster attack. Although varicella zoster virus vasculopathy is a well-documented complication that may induce a stroke postherpes zoster attack, it does not fully account for the unexpectedly high risk of stroke in these patients.
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------>authors2=Chien CW
------>authors3=Ho JD
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------>authors=Lin HC
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------>updateTitle=Increased risk of stroke after a herpes zoster attack: a population-based follow-up study.
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------>publish_year=2009
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z