| Liu KJ |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=3.432 ------>paper_class3=2 ------>paper_class2=1 ------>vol= ------>confirm_bywho=None ------>insert_bywho=cmbsycl ------>Jurnal_Rank=31.4 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=0 ------>page2= ------>medlineContent= ------>unit=E0104 ------>insert_date=20091106 ------>iam=2 ------>update_date=None ------>author=??? ------>change_event=1 ------>ISSN= ------>authors_c= ------>score=405 ------>journal_name=Immunology ------>paper_name=Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced Th2 responses in a mouse model of asthma. ------>confirm_date=None ------>tch_id=083006 ------>pmid=19909376 ------>page1= ------>fullAbstract=Summary Asthma is a chronic disease characterized by airway inflammation caused by the dysregulated production of cytokines secreted by allergen-specific type 2 T helper (Th2) cells. Antrodia camphorata is a commonly used fungus in Asian folk medicine, and A. camphorata polysaccharides are reported to possess anti-cancer activities. In this study, the immunomodulatory effects of purified fractionated polysaccharides (GF2) from A. camphorata on dendritic cells (DCs) and their potential preventive effects against ovalbumin (OVA) -induced asthma were investigated. In the presence of GF2, lipopolysaccharide (LPS) -activated DCs exhibited up-regulated expression of major histocompatibility complex (MHC) class II and co-stimulatory molecules, as well as enhanced interleukin-10 (IL-10) and IL-12 production. GF2 treatment on LPS-activated DCs suppressed naive CD4(+) T-cell proliferation and Th2 cell polarization with IL-10 production in an allogeneic mixed lymphocyte reaction. In animal experiments, a high dose of GF2 efficiently reduced expression levels of OVA-specific immunoglobulin G1 (IgG1) and IgE. However, lower doses of GF2 significantly enhanced OVA-specific IgG2a production. Our data also showed that administration of GF2 dose-dependently inhibited the development of airway hyperresponsiveness, airway eosinophilia and Th2 responses. OVA-specific CD4(+) T cells from higher doses of GF2-treated mice had significantly lower proliferative capacities compared with control mice. Moreover, treatment with GF2 significantly increased the high levels of IL-10 and low levels of interferon-gamma produced by T cells. Taken together, these data indicate that administration of A. camphorata polysaccharides (GF2) may have therapeutic potential when used as an adjuvant for the immunomodulatory treatment of allergic asthma. ------>tmu_sno=None ------>sno=22872 ------>authors2=Leu SJ ------>authors3=Su CH ------>authors4=Chiang BL ------>authors5=Chen YL ------>authors6=Lee YL ------>authors6_c= ------>authors=Liu KJ ------>delete_flag=0 ------>SCI_JNo=72105 ------>authors2_c= ------>publish_area=0 ------>updateTitle=Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no= ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=10 |