Yang LY |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=5.479 ------>paper_class3=2 ------>paper_class2=3 ------>vol=5 ------>confirm_bywho=hsuan ------>insert_bywho=yangly ------>Jurnal_Rank=21.7 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=0 ------>page2=572 ------>medlineContent= ------>unit=E0105 ------>insert_date=20091111 ------>iam=1 ------>update_date=None ------>author=??? ------>change_event=4 ------>ISSN= ------>authors_c= ------>score=500 ------>journal_name=Autophagy ------>paper_name=The cadmium-induced death of mesangial cells results in nephrotoxicity ------>confirm_date=20091112 ------>tch_id=089108 ------>pmid=19333000 ------>page1=571 ------>fullAbstract=This study summarizes our most recent findings on the mechanisms underlying the cadmium-induced death of mesangial cells, which leads to nephrotoxicity. Multiple pathways participate in cadmium-induced nephrotoxicity. In the ROS-GSK-3beta autophagy pathway, cadmium induces ROS most likely from the mitochondria, and the ROS consequently activate GSK-3beta leading to autophagic cell death. In the calcium-ERK autophagy and apoptosis pathway, cadmium stimulates calcium release from the endoplasmic reticulum, which activates ERK leading to predominantly autophagic cell death and a minor level of apoptotic cell death. In the calcium-mitochondria-caspase apoptosis pathway, cadmium-induced elevation of calcium depolarizes the mitochondrial membrane potential and then activates caspase signaling leading to apoptosis. A proposed model for cadmium-induced autophagy and apoptosis leading to nephrotoxicity is summarized in Figure 1. ------>tmu_sno=None ------>sno=22917 ------>authors2=Wu KH ------>authors3=Chiu WT ------>authors4=Wang SH ------>authors5=Shih CM ------>authors6= ------>authors6_c= ------>authors=Yang LY ------>delete_flag=0 ------>SCI_JNo=68168 ------>authors2_c= ------>publish_area=0 ------>updateTitle=The cadmium-induced death of mesangial cells results in nephrotoxicity. ------>language=2 ------>check_flag=None ------>submit_date=None ------>country=None ------>no=4 ------>patent_SDate=None ------>update_bywho=None ------>publish_year=2009 ------>submit_flag=None ------>publish_month=5 |