Song-Chow Lin, |
------>authors3_c= ------>paper_class1=1 ------>Impact_Factor=0.743 ------>paper_class3=2 ------>paper_class2=1 ------>vol=28 ------>confirm_bywho=leehorng ------>insert_bywho=chungtc ------>Jurnal_Rank=60.0 ------>authors4_c= ------>comm_author= ------>patent_EDate=None ------>authors5_c= ------>publish_day=1 ------>paper_class2Letter=None ------>page2=174 ------>medlineContent= ------>unit=E0310 ------>insert_date=20001020 ------>iam=2 ------>update_date= ------>author=??? ------>change_event=4 ------>ISSN=0192-415X ------>authors_c= ------>score=500 ------>journal_name=The American Journal of Chinese Medicine ------>paper_name=Hepatoprotective Effects of Arctium Lappa on Carbon Tetrachloride- and Acetaminophen-Induced Liver Damage ------>confirm_date=20071127 ------>tch_id=059003 ------>pmid=10999435 ------>page1=163 ------>fullAbstract=The root of Arctium lappa Linne (A. lappa) (Compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. In order to investigate the hepatoprotective effects of A. lappa, male ICR mice were injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.). A. lappa suppressed the SGOT and SGPT elevations induced by CCl4 or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. A. lappa reversed the decrease in GSH and P-450 induced by CCl4 and acetaminophen. It was also found that A. lappa decreased the malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice. From these results, it was suggested that A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen. ------>tmu_sno=None ------>sno=2459 ------>authors2=Tsao-Chuen Chung*, ------>authors3=Chun-Ching Lin ------>authors4=Tzuu-Huei Ueng ------>authors5=Yun-Ho Lin ------>authors6=Shuw-Yuan Lin and Li-Ya Wang ------>authors6_c= ------>authors=Song-Chow Lin, ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c= ------>publish_area=0 ------>updateTitle=Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no=2 ------>patent_SDate=None ------>update_bywho= ------>publish_year=2000 ------>submit_flag= ------>publish_month=1 |