Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Song-Chow Lin,
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------>ISSN=0192-415X
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------>journal_name=The American Journal of Chinese Medicine
------>paper_name=Hepatoprotective Effects of Arctium Lappa on Carbon Tetrachloride- and Acetaminophen-Induced Liver Damage
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------>fullAbstract=The root of Arctium lappa Linne (A. lappa) (Compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. In order to investigate the hepatoprotective effects of A. lappa, male ICR mice were injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.). A. lappa suppressed the SGOT and SGPT elevations induced by CCl4 or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. A. lappa reversed the decrease in GSH and P-450 induced by CCl4 and acetaminophen. It was also found that A. lappa decreased the malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice. From these results, it was suggested that A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen.
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------>authors2=Tsao-Chuen Chung*,
------>authors3=Chun-Ching Lin
------>authors4=Tzuu-Huei Ueng
------>authors5=Yun-Ho Lin
------>authors6=Shuw-Yuan Lin and Li-Ya Wang
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------>authors=Song-Chow Lin,
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------>updateTitle=Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage.
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------>publish_year=2000
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z