| Song-chow Lin, Tsao-chun Chung, Chun-ching Lin, Tzuu-Huei Ueng, Yun-ho Lin, Shuw-yuan Lin and Li-ya Wang |
------>authors3_c=None ------>paper_class1=1 ------>Impact_Factor=None ------>paper_class3=2 ------>paper_class2=1 ------>vol=28 ------>confirm_bywho=sheujr ------>insert_bywho=songchow ------>Jurnal_Rank=None ------>authors4_c=None ------>comm_author=1 ------>patent_EDate=None ------>authors5_c=None ------>publish_day=None ------>paper_class2Letter=None ------>page2=173 ------>medlineContent= ------>unit=E0106 ------>insert_date=20001021 ------>iam=1 ------>update_date= ------>author=??? ------>change_event=5 ------>ISSN=None ------>authors_c=None ------>score=500 ------>journal_name=American Journal of Chinese Medicine ------>paper_name=Hepatoprotective effects of Arctium Lappa on carbon-tetrachloride- and acetaminophen-induced liver damage ------>confirm_date=20010330 ------>tch_id=064001 ------>pmid=10999435 ------>page1=163 ------>fullAbstract=The root of Arctium lappa Linne (A. lappa) (Compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. In order to investigate the hepatoprotective effects of A. lappa, male ICR mice were injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.). A. lappa suppressed the SGOT and SGPT elevations induced by CCl4 or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. A. lappa reversed the decrease in GSH and P-450 induced by CCl4 and acetaminophen. It was also found that A. lappa decreased the malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice. From these results, it was suggested that A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen. ------>tmu_sno=None ------>sno=2462 ------>authors2=None ------>authors3=None ------>authors4=None ------>authors5=None ------>authors6=None ------>authors6_c=None ------>authors=Song-chow Lin, Tsao-chun Chung, Chun-ching Lin, Tzuu-Huei Ueng, Yun-ho Lin, Shuw-yuan Lin and Li-ya Wang ------>delete_flag=0 ------>SCI_JNo=None ------>authors2_c=None ------>publish_area=None ------>updateTitle=Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. ------>language=2 ------>check_flag= ------>submit_date= ------>country=None ------>no=2 ------>patent_SDate=None ------>update_bywho= ------>publish_year=2000 ------>submit_flag= ------>publish_month=None |