Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Jong YJ, Li H, Chang JG, Hsieh-Li HM, Lee HH, Lee CC, Wang NM, Tsai CH.
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------>journal_name=Kao Hsiung I Hsueh Ko Hsueh Tsa Chih.
------>paper_name=Analysis of an SMN gene-like DNA fragment
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------>fullAbstract=Part of a survival motor neuron (SMN) gene-like DNA fragment has been identified. This DNA fragment was accidentally isolated from cDNA by RT-PCR using primers specific for the region between exon 3 and 6 of the SMN gene. This fragment was used as a probe to hybridize the mRNA from several tissues, but we have been unable to detect any transcript of this SMN-like gene in these tissues. Thus, we have inferred this SMN gene-like fragment was a genomic product contaminant that was amplified in the reaction. Sequencing analysis of this fragment, which contains several stop codons, revealed a 74.6% nucleotide homology with the SMN gene. From these results, we believe that this DNA fragment is not a mutated form of SMN gene. Rather, it is an SMN-like pseudogene, which is variably present even in normal individuals.
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------>authors=Jong YJ, Li H, Chang JG, Hsieh-Li HM, Lee HH, Lee CC, Wang NM, Tsai CH.
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------>updateTitle=Analysis of an SMN gene-like DNA fragment.
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------>publish_year=2000
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z