Taipei Medical University

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Ko WC, Kuo SW, Sheu JR, Lin CH, Tzeng SH and Chen CM
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------>journal_name=Planta Medica
------>paper_name=Relaxant effects of quercetin methyl ether derivatives in isolated guinea pig trachea and their structure-activity relationships.
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------>fullAbstract=In the present study, we attempted to compare quercetin methyl ethers and to look for the structure-activity relationships, which may be helpful for synthesizing more active compounds for the treatment of asthma. Four present and two previously studied quercetin methyl ethers concentration-dependently relaxed histamine (30 microM), carbachol (0.2 microM) and KCl (30 mM) induced precontraction. According to their IC25 values to histamine-induced precontraction, the potency order was quercetin 3,3~,4,~5,7-pentamethyl ether (QPME), quercetin 3-methyl ether > quercetin, quercetin 3,4~,7-trimethyl ether (ayanin) > quercetin 4~-methyl ether (tamarixetin), quercetin 3,3~,4~,7,-tetramethyl ether (QTME). Therefore, the methylation at 3, at 5, and at both 3 and 7 positions of the A or/and C ring of quercetin nucleus may increase their tracheal relaxant activity. However, the methylation at the 3~ and at the 4~ position of the B ring of quercetin nucleus may decrease their tracheal relaxant activity.
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------>authors=Ko WC, Kuo SW, Sheu JR, Lin CH, Tzeng SH and Chen CM
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------>updateTitle=Relaxant effects of quercetin methyl ether derivatives in isolated guinea pig trachea and their structure-activity relationships.
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------>publish_year=1999
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z